1 / 8

t cell development

Altering the specificity of T cell receptor (TCR) is one of the popular strategies to genetically modify T cells to enhance the tumor-killing activity of T cells. <br>

bellasmith123
Download Presentation

t cell development

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. t cell development https://www.creative-biolabs.com/car-t

  2. Altering the specificity of T cell receptor (TCR) is one of the popular strategies to genetically modify T cells to enhance the tumor-killing activity of T cells.

  3. LOGO tcr t cell The T cell receptor (TCR), found on the surface of T cells, is responsible for antigen recognition. It consists of two chains: the alpha (α) and beta (β) chains. Both chains have a constant region (c) and a variable region (v), and it is the variable region that determines antigen specificity. The TCR is associated with the CD3 complex, which comprises three transmembrane signalling molecules (CD3ζζ, CD3δε and CD3γε).

  4. A TCR will interact with an antigen on a target cell when the target peptide sequence is presented by the appropriate major histocompatibility complex (MHC-1 for cytotoxic T cells). Efficient T-cell activation also requires the simultaneous binding of the T cell co-receptor (CD8 for cytotoxic T cells). ss, disulphide bridge.

  5. Altering the specificity of T cell receptor (TCR) is one of the popular strategies to genetically modify T cells to enhance the tumor-killing activity of T cells.

  6. tcr technology With high-affinity TCR technology, Creative Biolabs is capable of identifying the candidate target tumor antigen and the sequence of tumor-specific TCR to create tumor-specific T cells. We have high qualified groups and advanced technologies to perform TCR engineering services covering every unit of manufacturing and delivery pipeline. From a tumor-reactive T cell or active anti-tumor T-cell antigens, the appropriate target sequence is introduced to modify T cells to target a broad range of tumors with improved specificity.

  7. Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA Email: marketing@creative-biolabs.com

More Related