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West Nile Virus

West Nile Virus. 3-D Project Microbiology Fall 2005 Jeff Dooley. Model Information. Scale = 1:10 7 (1 nm = 1 cm). MODEL…………………VIRUS Diameter - 40 cm………40 nm RNA length 27.5 m…….2750 nm RNA = 11,000 base pairs. http://www.rkm.com.au/biograph.html. The History.

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West Nile Virus

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  1. West Nile Virus 3-D Project Microbiology Fall 2005 Jeff Dooley

  2. Model Information • Scale = 1:107 (1 nm = 1 cm) • MODEL…………………VIRUS • Diameter - 40 cm………40 nm • RNA length 27.5 m…….2750 nm • RNA = 11,000 base pairs http://www.rkm.com.au/biograph.html

  3. The History • The virus was first discovered in 1937 in Uganda. http://worldatlas.com/webimage/countrys/africa/ug.htm

  4. Description • The West Nile Virus (WNV) is commonly found in Africa, West Asia, and the Middle East. • Causes Potentially Serious illness (neurological diseases: encephalitis, meningitis) • Mosquito-borne ssRNA virus http://www.nature.com/nm/journal/v10/n12/full/nm1140.html http://www.tinymosquito.com/images/denguefever.jpg

  5. Virology: Classification • Family:Flaviviridae(Flavius is yellow in Latin) • Genus:Flavivirus Japanese Encephalitis Antigenic Complex • Complexes:Alfuy, Cacipacore, Japanese encephalitis, Koutango, Kunjin, Murray encephalitis, St. Louis encephalitis, Rocio, Stratford, Usutu, West Nile, and Yaounde viruses • Flaviviruses:40-60 nm (enveloped icosahedra nucleocapsid)

  6. Anatomy • E-Protein: Envelope proteins on surface for protection • M-Protein: Matrix Glycoprotein assembles virus • C-Protein: Capsid/Core protein contains RNA • Capsule/Membrane provides structure

  7. West Nile Virus in California • As of 11/8/2005: • 54 counties have reported WNV activity in California this year. • 895 people infected in 40 counties in 2005. • There have been 18 WNV-related fatalities. • 453 horses* have tested positive for WNV in 42 counties, of these 199 have died or been euthanized. • 2,976 dead birds in 52 counties have tested positive for WNV. • 1,236 mosquito pools** from 29 counties have tested positive for WNV. • 1,034 sentinel chickens from 31 counties have tested positive for West Nile/Saint Louis Encephalitis (SLE)*** antibodies. http://www.westnile.ca.gov/

  8. Symptoms • Most infected people are asymptomatic (80%) • 3-14 days after infection • Rash, fever (101-104 F) • Rarely affect the brain (may induce coma, encephalitis, meningitis) • Stiff neck, convulsions, weakness, paralysis http://www.tinymosquito.com/images/denguefever.jpg

  9. Treatments • Currently no treatment available • Life support may be required for encephalitis • Actively working on a vaccine (possibly hybrid genes with yellow fever virus) • Only vaccination available is for Equine use (1/3 cases end in death) http://7art-screensavers.com/screenshots/Graceful_Horses/elegant-horse.jpg

  10. References • http://www.nature.com/nm/journal/v10/n12/full/nm1140.html • http://www.rkm.com.au/VIRUS/WEST-NILE-VIRUS/West-Nile-Virus-Group.html • http://www.westnile.ca.gov/ • http://www.vh.org/adult/patient/internalmedicine/aba30/2002/westnile.html • http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/V/Viruses.html • http://www.cabq.gov/envhealth/wnvinfo.html

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