Membranes and transport intracellular and extracellular compartments Extracellular matrix

1. Membranes andtransport intracellular and extracellular compartments Extracellular matrix Transport across cell membrane diffusion- simple and facilitated osmosis active transport What is the membrane potential? What is cell signaling?

3. Purposes of ECM Support Adhesion Signaling Recognition

5. Types of diffusion (passive transport) Simple Facilitated Membrane is selectively permeable

7. Can be open or gated (“channel blockers”

8. Osmosis movement of water across membrane Water moves when solute cannot (and when solute concentrations are unequal)

10. Increases with solute concentration

13. Tonicity of solution- affects movement of water Isotonic- water will not move (I.e., solution has same osmolality) Hypotonic- water moves in Hypertonic- water moves out What does that do to the cell?

15. “Osmotically active” substances Cannot move across membranes themselves Therefore influence osmosis Plasma proteins are osmotically active blood moves form tissues to blood because protein concentration in blood is higher than in tissues What happens if plasma protein concentration is abnormally low?

17. Carrier-mediated transport some molecules are too big or too polar to diffuse through lipid bilayer Specificity Competition Saturation Example: glycosuria Facilitated diffusion: energy not required down concentration gradient

19. inducible