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caspase 3, apoptosis-related cysteine peptidase

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

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caspase 3, apoptosis-related cysteine peptidase

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  1. CASP3 caspase 3, apoptosis-related cysteine peptidase BackgroundThis gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. SynonymsCASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; Apopain; CPP-32; EC 3.4.22.56; Yama; procaspase3; Cysteine protease CPP32; PARP cleavage protease; SREBP cleavage activity 1; Yama protein; caspase 3, apoptosis-related cysteine protease Recombinant Proteins Cell & Tissue Lysates

  2. Others Cat.# Product name Source (Host) Species Tag Price CASP3-0421H Recombinant Human CASP3 Protein, GST-Tagged Wheat Germ Human GST +Inquiry CASP3-1642H Recombinant Human Caspase 3, Apoptosis-related Cysteine Peptidase E. coli Human N/A +Inquiry Casp3-1641M Recombinant Mouse Caspase 3 E. coli Mouse N/A +Inquiry Casp3-1644R Recombinant Rat Caspase 3 E. coli Rat N/A +Inquiry CASP3-158H Recombinant Human CASP3 E. coli Human +Inquiry CASP3-192H Recombinant Human CASP3, Met&His-tagged E. coli Human Met/His +Inquiry CASP3-293H Recombinant Human CASP3 protein, His/MBP-tagged E. coli Human His/MBP +Inquiry CASP3-334H Recombinant Human CASP3 protein, GST-tagged Wheat Germ Human GST +Inquiry CASP3-342H Recombinant Human CASP3, His tagged E. coli Human His+Inquiry CASP3-621H Recombinant Human CASP3 protein, His-tagged

  3. E. coli Human His+Inquiry CASP3-622H Recombinant Human CASP3 protein, His & T7-tagged E. coli Human His/T7+Inquiry Casp3-1643M Recombinant Mouse Casp3 protein E. coli Mouse N/A +Inquiry Casp3-623M Recombinant Mouse Casp3 protein, His-tagged E. coli Mouse His+Inquiry CASP3-1145R Recombinant Rat CASP3 Protein Mammalian Cells Rat His+Inquiry Casp3-624R Recombinant Rat Casp3 protein, His & T7-tagged E. coli Rat His/T7+Inquiry Casp3-625R Recombinant Rat Casp3 protein, His & T7-tagged E. coli Rat His/T7+Inquiry CASP3-362C Recombinant Cynomolgus CASP3 Protein, His-tagged Mammalian Cells Cynomolgus Monkey His +Inquiry CASP3-6290C Recombinant Chicken CASP3Mammalian Cells Chicken His+Inquiry CASP3-36H Recombinant Human CASP3, His-tagged E. coli Human His+Inquiry Casp3-748R Recombinant Rat Caspase 3, His-tagged E. coli Rat His+Inquiry

  4. Involved Pathway Casp3 involved in several pathways and played different roles in them. We selected most pathways Casp3 participated on our site, such as MAPK signaling pathway, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Casp3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway NamePathway Related Protein MAPK signaling pathwayNF1; ECSIT; RPS6KA3A; PAK2A; HSPB1; PPM1B; MEF2CB; TGFBR1; FGF6B; MAP3K6 p signaling pathwayIGFBP3; SESN1; PERP; CCND3; SERPINB5; SESN2; LRDD; COP1; RPRM; BID ApoptosisMAP3K14; H1F0; CASP10; IRAK1; CFLAR; Gzmg; TNFRSF10D; IL3; DFFA; ADD1 Natural killer cell mediated cytotoxicityITGAL; PIK3CB; ULBP3; PLCG2; HCST; MAPK1; FAS; HLA-G; ZAP70; CD48 TNF signaling pathwayCREB3L3; MAPK3; FOS; LIF; TNF; TRADD; MMP14; RELA; PIK3R5; MAPK13 Serotonergic synapseGNB3; KCND2; KCNN2; ALOX12; PLA2G4C; TRPC1; NRAS; SLC18A2; GNG12; PLCB4 Non-alcoholic fatty liver disease (NAFLD)UQCRB; INS; FAS; BID;

  5. PRKAA1; NDUFA12; NDUFB6; TGFB1; NDUFA4; SREBF1 Alzheimers diseaseEIF2AK3; COX4I1; ATP2A3; PPP3R2; UQCRC2; FADD; PSEN1; SDHC; NDUFB11; MAPK1 Parkinsons diseaseCASP9; COX7B; ATP5O; NDUFB8; ATP5H; SLC6A3; NDUFB10; NDUFV1; UBE2G1; PRKACA Amyotrophic lateral sclerosis (ALS)GRIN1; CASP1; CYCS; NEFM; RAC1; CAT; MAPK12; MAP2K6; CCS; GRIN2C Huntingtons diseaseDNALI1; DNAH5; CASP8; NDUFA12; GNAQ; NDUFB7; NDUFS5; NDUFA7; SDHD; REST PertussisC3; SERPING1; NLRP3; IL6; MAPK8; CALM2; Casp3; MAPK11; NFKB1; ITGA5 LegionellosisRAB1A; C3; PYCARD; SAR1B; NFKB1; IL12A; ITGB2; BCL2L13; ITGB2L; CD14 ToxoplasmosisIFNGR1; GNAI1; PIK3CD; SOCS1; LAMA4; TRAF6; ALOX5; MAP2K3; CASP9; NOS2 AmoebiasisCOL5A1; IL1B2; AASS; TLR2; SERPINB10; PLCB3; NFKB1; SERPINB6; CD1d1; TGFB3 TuberculosisRAB7; FCGR1; ITGB2; ATP6V0D2; ATP6V1H; IL18; IL23; MAPK8; IFNA8; NFYA Hepatitis BSMAD3; AKT1; BAD; IFNA8; PIK3R1; IFNA14; CREB3L3; PTEN; MMP9; NRAS Herpes simplex infectionDDX58; SKP2; Casp3; C1QBP; SRSF7B;

  6. MCRS1; HNRPKL; PML; SRSF2B; BF2 Pathways in cancerRALBP1; FGF12; FZD7; LAMB2; TRAF3; VEGFC; TGFB2; GRB2; ROCK1; PLCB2 Viral carcinogenesisCCNA2; HIST1H2BE; MRPS18B; YWHAG; CCND1; SP100; H2-Q10; CASP8; HLA-B; RBPJ Proteoglycans in cancerTGFB2; HSPG2; PIK3CD; TFAP4; MRAS; ELK1; FZD9; WNT11; ARAF; FAS MicroRNAs in cancerWNT3; STAT3; APC; MARCKS; ERBB2; EP300; BMPR2; TNR; GLS; THBS1 Colorectal cancerSMAD3; AKT2; TCF7L2; TCF7; DCC; TRP53; TGFBR2; PIK3R3; RAC2; MAPK10 Viral myocarditisHLA-DQB1; CASP9; HLA-DRB4; HLA-DMA; RAC2; ICAM1; CD80; HLA-DOB; HLA-E; CXADR Protein Function Casp3 has several biochemical functions, for example, aspartic-type endopeptidase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Casp3 itself. We selected most functions Casp3 had, and list some proteins which have the same functions with Casp3. You can find most of the proteins on our site.

  7. FunctionRelated Protein Function aspartic-type endopeptidase activityRelated Protein PGA; NRIP3; Ren1; PGA4; PGA5; ASPRV1; NRIP2; NOTS; SPPL2; SPPL3 Function cyclin-dependent protein serine/threonine kinase inhibitor activityRelated Protein CDKN2D; KAT2B; Casp3; CDKN1A; CDKN1BB; CDKN2C; CDKN2B; CDKN1B; HEXIM2; CDKN2A Function cysteine-type endopeptidase activityRelated Protein USP49; USP4; CTSS; USP17L5; CASP8; USP5; CTSBB; BLMH; CTSO; USP9X Function cysteine-type endopeptidase activity involved in apoptotic processRelated Protein Casp3; CLC; CASP8 Function cysteine-type endopeptidase activity involved in execution phase of apoptosisRelated Protein CASP6L2; CASP3A; Casp3; CASP3B; CASP7; CASP6L1; CASP6 Function cysteine-type peptidase activityRelated Protein CAPN3; CTSL2; CTLA2B; OTUD7B; USP17L1P; Ctsl; DESI2; CAPN12; USP17L3; CTS7 Function death receptor bindingRelated Protein BID; MYD88; TMBIM1; TNFSF15; FADD; FEM1B; PRDM4; NOL3; PIDD1; CFLAR Function hydrolase activityRelated Protein ABHD17B; DDHD1;

  8. RNASEL4; CAPN2A; CLCA5; OVCA2; G6PC3; ADPRM; ABCB1A; INPPL1B Function peptidase activityRelated Protein AZU1; CAPN11; ELA3L; PCSK5B; CAPN2A; PRSS59.1; OTUD7A; TPP1; CASP9; DHH Function phospholipase A2 activator activityRelated Protein Casp3; PLAA Function protease bindingRelated Protein INS2; ITGA3; LDLR; UBC; ITGB1; RFFL; COMP; TIMP2; ADRM1; Serpina1c Function protein bindingRelated Protein DDX39A; HESX1; TXNIP; NPBWR1; FAM134B; CLNK; GGNBP2; MYOD1; UBE2U; ZNRF1 Function protein complex bindingRelated Protein PAFAH1B1; PPP2R2A; STRN4; YWHAB; CDK5RAP1; SHANK1; PRMT5; NOG; CALCA; NSF Interacting Protein Casp3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Casp3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Casp3.

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