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2020/8/1 Functional Complement Assays - Profacgen (https://www.profacgen.com) Home (/) Services Products APP & TECH Contact Us About Us (https://www.profacgen.com/contact- (https://www.profacgen.com/about- us.htm) us.htm) Functional Complement Assays Home (http://www.profacgen.com) / Services / Protein Analysis (https://www.profacgen.com/protein-analysis.htm) Sign In (https://www.profacgen.com/SignIn.aspx) / Register / Complement Assays (https://www.profacgen.com/services/protein- analysis/complement-assays) (https://www.profacgen.com/SignUp.aspx) / Functional Complement Assays https://www.profacgen.com/functional-complement-assays.htm 1/6
2020/8/1 Functional Complement Assays - Profacgen Functional Complement Assays The complement system plays an essential role in chronic, autoimmune and infectious diseases. It contains a group of proteins that when activated lead to target cell lysis and facilitate phagocytosis through opsonization. This system of plasma proteins can be activated directly by pathogens or indirectly by pathogen- bound antibody, leading to a cascade of reactions involving more than 35 proteins that occurs on the surface of pathogens and generates active components with various effector functions. There are three pathways of complement activation, namely the classical, the alternative and the recently discovered MB-lectin pathway. To study the functional activity of complement pathways, labelled antibodies specific for neoantigen produced as a result of complement activation are used to measure the presence of complement components. If a complement component is absent, the total complement activity will be zero; if one or more components of the classical pathway decreas, the activity will be down-regulated. Profacgen provides a complete solution for complement function assays. The highly sensitive assays enable determination of specific activity of each of the three pathways separately without interference from the others. With years of experience, https://www.profacgen.com/functional-complement-assays.htm 2/6
2020/8/1 Functional Complement Assays - Profacgen our in-house laboratory services have been developed to perform in compliance with GLP, GCP and ISO 17025, ensuring that regulatory requirements are met. A comprehensive menu of markers for complement function and activation is available, as well as test packages for assessment of complement deficiencies and complement function. Profacgen provides complement function assays for various applications in drug development and clinical research: Drug development - potency of complement-targeted therapies Clinical studies - monitoring of complement function/activity Off-target complement reactions Features Highly sensitive, robust and standardized assays Fast and reliable Flexibility - assay adaptations possible for individual research protocols Automation - high-throughput options with validated protocols are available Agreement with haemolytic assays (CH50, APH50) Assay Services Complement System Classical Pathway Complement System Alternative Pathway Complement System MB-lectin Pathway Reference 1. Mathern, D.R., Heeger, P.S. (2015) Molecules great and small: The complement system. Clinical Journal of the American Society of Nephrology. 10 (9): 1636-1650. https://www.profacgen.com/functional-complement-assays.htm 3/6
2020/8/1 Functional Complement Assays - Profacgen Figure 1 Overview of the complement cascade. SERVICES Protein Production (https://www.profacgen.com/protein-production.htm) Bioinformatics Platform Introduction (https://www.profacgen.com/Bioinformatics-Platform-Introduction.htm) Protein Analysis (https://www.profacgen.com/protein-analysis.htm) Complement Assays (https://www.profacgen.com/services/protein-analysis/c… * Complement Component Assays (https://www.profacgen.com/complement-com… * Functional Complement Assays (https://www.profacgen.com/functional-comple… * https://www.profacgen.com/functional-complement-assays.htm 4/6
2020/8/1 Functional Complement Assays - Profacgen Enzyme Activity Assay Service (https://www.profacgen.com/enzyme-activity-… * Nucleic Acid-Protein Interactions (https://www.profacgen.com/services/protei… * Optogenetics services (https://www.profacgen.com/services/optogenetics-se… * Plasma Protein Binding Assay (https://www.profacgen.com/services/protein-… * Protein Aggregation Analysis (https://www.profacgen.com/protein-aggregati… * Protein Interaction Analysis Services (https://www.profacgen.com/protein-int… * Screening and Profiling Services (https://www.profacgen.com/screening-and-… * Transcription Factor Analysis (https://www.profacgen.com/transcription-fact… * Biomarker Discovery and Development Service (https://www.profacgen.com/… * Genotoxic Impurities Analysis (https://www.profacgen.com/services/protein-… * Drug Development (https://www.profacgen.com/drug-development.htm) INQUIRY (https://www.profacgen.com/order.htm?i1=Functional Complement Assays) CONTACT US Email: info@profacgen.com Tel: 1-631-448-8149 Fax: 1-631-938-8127 45-1 Ramsey Road, Shirley, NY 11967, USA Copyright ©2010 - 2020 Profacgen. All rights reserved. | Terms and Conditions (https://www.profacgen.com/term-and- conditions.htm) | Privacy Policy (https://www.profacgen.com/privacy-policy.htm) https://www.profacgen.com/functional-complement-assays.htm 5/6
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