medicinal plants used in the treatment of cancer

1. Plant Drug Used In The Management of CANCER Seminar Presented By: Asad Shah Under the guidence of: Ms P.P Udapurkar (M.Pharm)

2. Contents • Introduction • Plant drugs

3. Introduction • Cancer, also known as a malignant tumor or malignant neoplasm, is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. • A neoplasm or tumor is a group of cells that have undergone unregulated growth, and will often form a mass or lump, but may be distributed diffusely.

4. Sign and Symptoms • Possible signs and symptoms include: a new lump, abnormal bleeding, a prolonged cough, unexplained weight loss, and a change in bowel movements among others. • While these symptoms may indicate cancer, they may also occur due to other issues. • When cancer begins, it invariably produces no symptoms. Signs and symptoms only appear as the mass continues to grow or ulcerates. The findings that result depend on the type and location of the cancer.

5. Mutation of Cancer Cancers are caused by a series of mutations. Each mutation alters the behavior of the cell somewhat.

6. Medicinal Plants used in the Treatment of Cancer

7. 1.VINCA • Synonyms and Regional name: VincaroseaSadaphuli, Rattanjot; Hindi- Sadabahar • Biological source: It is dried whole plant of Catharanthusroseus. • Family: Apocynaceae

8. CHEMICAL CONSTITUENTS 1. Indole and indoline alkaloids: Ajmalicine,Lochnerine,Serpentineand 2. Tetrahydroalstonine: DimericIndole bases of monoterpene type Vinblastin,Vincristin.

9. 2.WITHANIA • Synonym; Ashwagandha,Asgandh Biological Source: It is dried root and rhizomes of the plan Withaniasomnifera. Family; Solanaceae

10. Chemical constituent • Alkaloids • Withanolide A , withaferine, Withanone etc

11. 3.Podophyllum • Synonyms: Indian Podophyllum, Podophyllum radix. • Biological source: It consists of the dried rhizome and root of PodophyllumhexandrumRoyl. American podophyllum consists of dried rhizomes and roots of P. peltatum. • Family: Berbiridiaceae

12. Chemical constituents • It contains Podophyllin resin is known as podophyllotoxin. α and β peltatins are present only in the American podophyllum.

13. 4.Cascara Bark • Synonyms chittenbark;Persianbark; Bearbark,Bearwood; Cascara bark; Rhamnipurshianae. • Biological Source Cascara sagrada is the dried bark of RhamanuspurshianaDC., family Rhamnaceae,.

14. Chemical constituents The cascara sagradabark is found to contain two major types of anthracene compounds, namely:Normal O-Glycosides and Aloin-like C-Glycosides . The two C-glycosides are known as barbaloinand deoxybarbaloin.

15. 5.Turmeric • Synonyms : Curcuma; Indian Saffron; Tumeric. • Biological Source: Turmeric is obtained from the rhizome of Curcuma longaLinn. Famiily: Zingiberaceae.

16. Chemical constituents • it contains volatile oil (5-6%), resin and substantial quantity of zingiberaceous starch grains. The marked and pronounced yellow colour in turmeric is due to the presence of curcuminoidswhich essentially contains curcumin.

17. 6.Garlic • Synonyms: Lehsun, Rasun, Belluli, Vallaippundu, Garlic. • Biological source: Lehsunconsists of the fresh compound bulb of Alliumsativum Linn. • Family: Liliaceae.

18. Chemical constituents Essential oil: Alliin, a sulphur containing amino acid. Allicin- allylsulphide. Polysulphideresponsible for the unpleasant smell of the oil Amino acid: Leucine, methionine, Vitamins: A, B, C and D Fatty acid, mucilage and albumin. Minerals: Calcium, Iron and Zin

19. Reference • Wikipediia • Text book of Pharmacognosy by Gokhle,Kokate and Prohit • Practical Pharmacognosy by Khandelwal • www.pharmacognosydrugs.com • www.yourarticlelibrary.com

20. DRUGS IN MARKET

21. THANK YOU