1 / 7

activin A receptor, type I

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta);superfamily of structurally related signaling proteins.

Benmoney123
Download Presentation

activin A receptor, type I

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. a acvr1 cvr1 Official Full Name Official Full Name activin A receptor, type I Background Background Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta);superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor;serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors;are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a;transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are;essential for signaling; and type II receptors are required for binding ligands and for expression of type I;receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I;receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional;response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia;ossificans progressive. Synonyms Synonyms ACVR1; activin A receptor, type I; ACVRLK2; activin receptor type-1; ACVR1A; ALK2; SKR1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; se Recombinant Recombinant Proteins Proteins  Cell & Tissue Lysates Cell & Tissue Lysates Source Source (Host) (Host) Cat.# Cat.# Produc Product name t name Species Species Tag Tag Price Price ACVR1- 1022H Recombinant Human ACVR1 Protein, MYC/DDK-tagged HEK293 Human MYC/DDK +Inquiry

  2. Source Source (Host) (Host) Cat.# Cat.# Produc Product name t name Species Species Tag Tag Price Price ACVR1- 527H Recombinant Human ACVR1 Protein, His/Fc- tagged HEK293 Human His/Fc +Inquiry ACVR1- 01H Recombinant Human Activin A Receptor, Type I Sf 9 Insect cells Human +Inquiry ACVR1- 1408H Recombinant Human Activin A Receptor, Type I Baculovirus- Insect Cells Human N/A +Inquiry ACVR1- 1583H Recombinant Human Activin A Receptor, Type I NS0 Human N/A +Inquiry ACVR1- 199H Recombinant Human ACVR1 Protein, His- tagged Baculovirus- Insect Cells Human His +Inquiry ACVR1- 201H Recombinant Human ACVR1(R206H), GST- tagged Sf 9 Insect cells Human GST +Inquiry ACVR1- 239H Recombinant Human Activin A Receptor, Type I, GST-tagged, Active Sf 9 Insect cells Human GST +Inquiry ACVR1- 245H Recombinant Human ACVR1 Protein, GST- His-tagged Insect Cell Human GST/His +Inquiry

  3. Source Source (Host) (Host) Cat.# Cat.# Produc Product name t name Species Species Tag Tag Price Price ACVR1- 246H Recombinant Human ACVR1 Protein, GST- tagged Insect Cell Human GST +Inquiry ACVR1- 247H Recombinant Human ACVR1 Protein, GST- tagged Wheat Germ Human GST +Inquiry ACVR1- 2595H Recombinant Human Activin A Receptor, Type I BTI-Tn-5B1-4 cells Human N/A +Inquiry ACVR1- 2743H Recombinant Human Activin A Receptor, Type I Nicotiana benthamiana Human N/A +Inquiry ACVR1- 32H Recombinant Human ALK2 (Q207D), GST-tagged Sf 9 Insect cells Human GST +Inquiry ACVR1- 33H Recombinant Human ALK2 (Q207E), GST-tagged Sf 9 Insect cells Human GST +Inquiry ACVR1- 37H Recombinant Human ACVR1, GST-tagged Sf 9 Insect cells Human GST +Inquiry ACVR1- 38H Recombinant Human ALK2 Mutant (Q207E), GST- tagged Sf 9 Insect cells Human GST +Inquiry ACVR1- 489H Recombinant Human Activin A Receptor, Type I, Fc Chimera HEK293 Human Fc +Inquiry

  4. Source Source (Host) (Host) Cat.# Cat.# Produc Product name t name Species Species Tag Tag Price Price ACVR1- 526H Recombinant Human ACVR1, Fc-tagged, Biotinylated Human cells Human Fc +Inquiry ACVR1- 5680H Recombinant Human ACVR1 protein, His- tagged E. coli Human His +Inquiry ACVR1- 5681H Recombinant Human ACVR1 protein, His & GST-tagged E. coli Human His/GST +Inquiry ACVR1- 9172H Recombinant Human ACVR1 Baculovirus- Insect Cells Human +Inquiry Acvr1- 5682M Recombinant Mouse Acvr1 protein, His- tagged E. coli Mouse His +Inquiry Acvr1- 775M Recombinant Mouse Acvr1, Fc-His tagged HEK293 Mouse FC/His +Inquiry Acvr1- 8719R Recombinant Rat Acvr1, Fc tagged HEK293 Rat Fc +Inquiry ACVR1- 8812C Recombinant Cynomolgus ACVR1, Fc tagged HEK293 Cynomolgus Monkey Fc +Inquiry ACVR1- 230R Recombinant Rhesus monkey ACVR1 Protein, His-tagged Mammalian Cells Rhesus Macaque His +Inquiry

  5. Source Source (Host) (Host) Cat.# Cat.# Produc Product name t name Species Species Tag Tag Price Price ACVR1- 160C Recombinant Canine ACVR1, Fc-tagged HEK293 Canine Fc +Inquiry ACVR1- 161C Recombinant Canine ACVR1, His-tagged HEK293 Canine His +Inquiry ACVR1- 300C Recombinant Canine ACVR1, His tagged HEK293 Canine FC/His +Inquiry ACVR1- 301C Recombinant Canine ACVR1, Fc tagged HEK293 Canine His +Inquiry ACVR1- 6129C Recombinant Chicken ACVR1 Mammalian Cells Chicken His +Inquiry ACVR1- 984H Recombinant Human Activin A Receptor, Type I, His-tagged Sf 9 Insect cells Human GST +Inquiry Involved Pathway ACVR1 involved in several pathways and played different roles in them. We selected most pathways ACVR1 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Name Pathway Related Pro Pathway Related Protein tein Cytokine-cytokine receptor interaction CCR3; KITB; PF4; IL3; CCL25; IL11RA2; TP-1; CCL21; IFNA5; IFNK TGF-beta signaling pathway

  6. NOG3; BMP8A; SMURF1; RPS6KB1B; TNF; TGFB3; PPP2CA; ROCK2B; TGFB2; ZFYVE16 Signaling pathways regulating pluripotency of stem cells NANOG; MAPK13; SMARCAD1; WNT7B; HAND1; PIK3R2; ID4; NRAS; SMAD9; MYF5 Protein Function ACVR1 has several biochemical functions, for example, ATP binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR1 itself. We selected most functions ACVR1 had, and list some proteins which have the same functions with ACVR1. You can find most of the proteins on our site. Function Function Related Protein Related Protein Function Function ATP binding Related Prote Related Protein in PC; AURKC; PSMC4; PKN1B; ABCD4; CDKL5; PARS2; PAK1; MASTL; BRAF Function Function SMAD binding Related Protein Related Protein BMP2; STUB1; TOB1; PRDM16; SOD3; HIPK2; SKILB; SKOR1; YY1; HMGA2 Function Function activin binding Related Protein Related Protein ENG; FKBP1A; TGFBR3; ACVRL1; ACVR2B; SMAD7; FST; ACVR1; FSTL3; SMURF1 Function Function contributes_to activin receptor activity, type I Related Protein Related Protein ACVR1; ACVRL1 Function Function metal ion binding Related Protein Related Protein KCNIP3A; CDH24; ADPRM; ZNF574; LIMCH1B; INSM1A; ZFP39; ZNF791; ZNF100; CAHZ Function Function peptide hormone binding Related Protein Related Protein GALR2; HCRTR2; AVPR1A; ACVR1; MC4R; HCRTR1; GCGR; CRHR2; ECE1; AGTR1A Function Function protein binding Related Protein Related Protein ASF1B; HAAO; FGA; REG3A; DIS3; USP9X; CCHCR1; GPS1; NDOR1; ARRB2 Function Function protein homodimerization activity Related Protein Related Protein SMAD3; Il6ra; S100A1; TRIM8; TNNC1; PDE2A; APOBEC3G; PRMT2; NAMPT; MTERFD3 Function Function protein kinase activity Related Protein Related Protein NEK2; TRIM28; PRKDC; ACVR1BA; GM711; CSNK1G3; PKN2; NLK2; STK38A; STK4 Function Function protein serine/threonine kinase activity Related Protein Related Protein CSNK1DB; HIPK4; PRKD2; SLKA; FASTK; STK35; STK19; PAK1; PDIK1L; GSK3B

  7. Function Function receptor signaling protein serine/threonine kinase activity Related Protein Related Protein BMPR2B; ACVR1C; ALPK2; ACVRL1; ACVR1L; TGFBR1; ACVR1; BMPR1AB; BMPR1BA; BMPR1AA Function Function transforming growth factor beta binding Related Protein Related Protein THBS1; CD109; ENG; ACVR1; ACVRL1; HYAL2; LTBP4; TGFBR3; TGFB3; LTBP1 Function Function transforming growth factor beta receptor activity, type I Related Protein Related Protein TGFBR1; ACVR1; BMPR1B Function Function transmembrane receptor protein serine/threonine kinase activity Related Protein Related Protein BMPR1BA; ACVR1L; ACVR1BA; ALPK2; BMPR2B; ACVR1; ACVRL1; BMPR1B; BMPR1AB; BMPR1BB Interacting Protein ACVR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR1. Smad6; Rab17; Rhod; Fbxo30; Ikbkb; Chn1; Nek8; Ubxn1; Fancl; Rab3b; Rhebl1; Plekhb1; TGFBR1; linkable pd173955 analogue; bosutinib; dasatinib; crizotinib

More Related