Efficacy of Acetaminophen Is Questioned Once Again

1. Efficacy ofAcetaminophen Is Questioned OnceAgain A study published in the British Journal of Medicine said that acetaminophen on the efficacy of spinal pain is not obvious, and the role for osteoarthritis is also negligible. The study also expressed concerns about the safety of the drug. Acetaminophen, also known as p-hydroxyacetanilide, acetaminophen or acetaminophen, is a common clinical fever and analgesic drugs, commonly used in fever, headache and other mild pain, but also the main ingredients for many cold medicine and painkillers. Many non-prescription drugs have acetaminophen ingredients, such as Tylenol, compound paracetamol tablets, and other kinds of species. Basic chemicals like doxyl could also be necessary for related research. Spinal pain, including cervical pain and lower back pain, is a common pain disease together with osteoarthritis. At present, the vast majority of clinical guidelines for acetaminophen as the treatment of these diseases are payed increasing attention, but evidence of this support are relatively weak or contradictory. Because acetaminophen is present in a variety of different types of medications, it is highly likely to cause overdose in ignorance or accidental use, and many studies have expressed concern about the safety of their maximum daily dose of 4000 mg. For these reasons, recently the National Institutes of Health and Clinical Excellence (NICE) has continued to make paracetamol as a recommended drug treatment of arthritis, which also caused some controversy. In the new study, researchers from the George Institute for International Health, University of Sydney, pointed out the efficacy and safety of acetaminophen in the treatment of lower back pain, hip and knee osteoarthritis. He also compared and analyzed with 13 randomized controlled trials to compare the efficacy with placebo. Among the 13 trials, 10 were for hip or knee osteoarthritis, with 3541 participants; the other 3 were for lower back pain, with 1825 participants. The researchers evaluated the drugs according to the criteria for pain relief, improved quality of life, and drug safety as well as patient compliance. Some people are wondering whether glyceryl laurate and hydrocinnamic acid can be sued for such study, which is still a in-process idea. The results showed that acetaminophen was ineffective for lower back pain and did not reduce pain or improve quality of life when compared with placebo. In osteoarthritis, compared with placebo, acetaminophen has no obvious effect and does not have clinical value. The researchers also found that acetaminophen, when compared to placebo, was more than four times more likely to result in abnormal liver function. In addition, there was no significant difference between acetaminophen and placebo in drug side effects and patient compliance. The current comparative study of this drug is only up to a maximum of six months, so more studies are needed later to determine the effect during a longer period of time. Nonetheless, the involved scientists concludes that acetaminophen recommended drug for hip or knee osteoarthritis, as well as the lower back pain. Source(Read full text): http://hannahrobertss.kinja.com/efficacy-of-acetaminophen-is-questioned-once-again-1788268202 should be reconsidered a clinically