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Generalized Pustular Psoriasis (GPP) is a severe form of skin disorder called psoriasis. GPP is caused by abnormal<br>inflammation.<br>
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Generalized Pustular Psoriasis (GPP) 01 Generalized Pustular Psoriasis (GPP) is a severe form of skin disorder called psoriasis. GPP is caused by abnormal inflammation. 02 Mutations occur in several genes, including IL36RN and CARD14. They increase the risk of developing Generalized PustularPsoriasis. IL-36Ra protein produced from the IL36RN gene blocks the activity of specific proteins for not promoting skin inflammation. IL36RN gene mutations involved in GPP reduce the amount of IL-36Ra protein in the skin. 03 04 Generalized Pustular Psoriasis (GPP) is more common in females as compared to males worldwide. • DelveInsight © 2019 | All rights reserved
GPP Epidemiology • Generalized Pustular Psoriasis (GPP) is a rare disease and is the rarest form of psoriasis. In patients with a family history of psoriasis or homozygous mutation of IL36RN, onset age is earlier. • GPP accounts for 0.6% • to 7% of all cases of psoriasis and age of onset is between 3 and 16 years. • GPP prevalence was 1.76 per million in France whereas Japan prevalence was 7.46 per million. GPP prevalence affects 2 per million in Europe and occurs in 0.6 per million in Japan. • DelveInsight © 2019 | All rights reserved
GPP Market Outlook GPP market scenario reveals lack of targeted GPP therapies for cure but there are some symptomatic GPP treatments which are being given to the patients. Disease severity and extent of skin involvement may be helpful to determine GPP treatment. Extensive research and development activities of companies to develop GPP therapies that will create a positive impact GPP market during the forecast period (2019-2028). Current research is focused on the development of biologic therapies targeting IL-1, IL-12/23p40, and IL-17A receptors. Anakinra is a biologic therapy and is an IL-1 receptor antagonist for treating GPP, and gevokizumab is an IL-1β inhibitor for treating GPP patients. Drugs in the clinical trials are expected to propel the growth of GPP drugs market in the upcoming years. • DelveInsight © 2019 | All rights reserved
GPP Emerging Drugs and Companies Drug: ANB019 by AnaptysBio GPP market dynamics is anticipated to change in the coming years owing to the rising awareness of the disease. This provides an opportunity for other companies to enter the market like AnaptysBio and BoehringerIngelheimthat are involved in developing GPP therapies. Drug: BI655130 by BoehringerIngelheim • DelveInsight © 2019 | All rights reserved
Complete Information For complete information on Generalized Pustular Psoriasis Market Insights, Epidemiology & Market Forecast-2028 please click the link below CLICK HERE OR Write Us At info@delveinsight.com • DelveInsight © 2019 | All rights reserved • DelveInsight © 2019 | All rights reserved
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Contact Us info@delveinsight.com +91-11-4568 9769 www.delveinsight.com blog/delveInsight/ twitter/delveInsight LinkedIn/delveInsight • DelveInsight © 2019 | All rights reserved