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CHAPTER 11

CHAPTER 11. BLOOD VESSELS. Blood Vessels. Normal Pathology. NORMAL. Vascular Wall Response Congenital Anomalies Arteriosclerosis Atherosclerosis Hypertension Aneurysms. Vasculitides Raynaud Phenomenon Veins Lymphatics Tumors Interventions. PATHOLOGY.

Gabriel
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CHAPTER 11

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  1. CHAPTER 11 BLOOD VESSELS

  2. Blood Vessels • Normal • Pathology

  3. NORMAL

  4. Vascular Wall Response Congenital Anomalies Arteriosclerosis Atherosclerosis Hypertension Aneurysms Vasculitides Raynaud Phenomenon Veins Lymphatics Tumors Interventions PATHOLOGY

  5. Vascular WallResponse to Injury • Endothelial Cells • Smooth Muscle • Development, Growth, Remodeling • Intimal Thickening

  6. Congenital Anomalies • AV (Arterio-Venous) Fistulas

  7. Ateriosclerosis

  8. Atherosclerosis • Natural History • Epidemiology • Risk Factors • Pathogenesis • Other Factors • Effects • Prevention

  9. Natural History/Consequences

  10. Epidemiology • Risk Factors • Age • Sex • Hyperlipidemia • Hypertension • Cigarette Smoking • Diabetes Mellitus • Other Factors

  11. Pathogenesis • Endothelial Injury • Inflammation • Lipids • Smooth Muscle Cells

  12. OTHER Factors • Oligoclonality • Infection

  13. EFFECTS

  14. PREVENTION

  15. HYPERTENSIVEVascular Disease • Pathogenesis of Hypertension • Normal Regulation • “Essential” Hypertension • Vascular Pathology • “Hyaline” Arteriolosclerosis • “Hyperplastic” Arteriolosclerosis

  16. ANEURYSMS • Abdominal • Syphilitic (Luetic) • Dissection

  17. Abdominal Aneurysms

  18. Syphilitic Aneurysms

  19. Dissection • Morphology • Pathogenesis • Clinical Course

  20. VASCULITIDES • Pathogenesis of NON-Infectious • Giant Cell Arteritis (GCA) • Takayasu Arteritis • Poly-(Peri-)arteritis Nodosa • Kawasaki Disease • Microscopic Polyangiitis • Wegener Granulomatosis • Thromboangiitis Obliterans (Buerger) • Vasculitis with other disorders • Infectious

  21. Pathology of NON-InfectiousVasculitides • Immune Complexes • Antineutrophil Antibodies • Anti-Endothelial Cell Antibodies

  22. GIANT CELL Arteritis

  23. Takayasu Arteritis

  24. PolyArteritis Nodosa

  25. Kawasaki Disease

  26. Microscopic Polyangiitisaka, Microscopic Polyarteritisaka, Hypersensitivity Vasculitisaka, “Leukocytoclastic” Vasculiitis

  27. Wegener Granulomatosis

  28. Thromboangiitis Obliterans(Buerger’s Disease)

  29. Vasculitis Associated WithOther Disorders

  30. Infectious Arteritis

  31. RaynaudPhenomenon

  32. Veins/Lymphatics • Varicose Veins • Thrombophlebitis/Phlebo-thrombosis • SVC/IVC Syndromes • Lymphangitis • Lymphedema

  33. Varicose Veins • Pathogenesis • Morphology • Course

  34. Thrombophlebitis

  35. SVC/IVC Syndromes

  36. Lymphangitis

  37. Lymphedema

  38. TUMORS • Benign • Intermediate • Malignant

  39. BENIGN • Hemangioma • Capillary • Cavernous • Pyogenic Granuloma • Lymphangioma • Glomus Tumor • Vascular Ectasis • Nevus Flammeus • “Spider” Telangiectasia (Arterial Spider) • Osler-Weber-Rendu (Hereditary Telangiectasia) • Bacillary Angiomatosis

  40. INTERMEDIATE • Kaposi sarcoma • Hemangioendothelioma

  41. MALIGNANT • Angiosarcoma • Hemangiopericytoma

  42. Vascular Interventions • Balloon Angioplasty • Endovascular Stents • Vascular Replacement (Grafts)

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