What is protein misfolding and its significance

1. What is protein misfolding and its significance? When we talk about proteins, we often think it as the food nutrient that we include in our daily meal. But proteins are also microscopic molecules that are present in the cells performing a vital and diverse job. Depending on its shape, proteins function in different ways., but misshapen proteins can cause a severe problem to a person’s life. This may result in difficulty in walking and moving, hallucinations, muscle stiffness, and much more. According to the researchers, the misfolding or tissue accumulation of proteins is something very common in living cells. Currently there are 30 percent human diseases that are associated with protein misfolding. It includes neurodegenerative diseases such as Alzheimer disease, Parkinson disease, Type II Diabetes, dialysis-related amyloidosis, etc. Though there is not any specific treatment or cure for the disease, but keeping the person safe and comfortable with proper medication can help the patient speedy recovery. Gain Therapeutics is the most trusted and reliable institution where health workers are working tirelessly in unlocking new treatment options for difficult-to-treat disorders characterized by protein misfolding, including lysosomal storage disorders. Why does protein misfolding occur and what is its importance? According to scientists and researchers, there are many reasons which may result in protein misfolding. Sometimes, accurate folding of proteins can go wrong due to below-mentioned reasons: When proteins are created, DNA gives direction to the machine how proper chains of amino acids are created. But, sometimes, this machine, the ribosome, makes mistakes which results in the improper folding of proteins. Secondly, even if amino acids don’t make any mistake, it may still not reach its definite shape as sometimes protein cells do not fold accurately 100%. If these protein cells are not folded properly, it can occur problem of "loss of function". For example, a protein cell helps in metabolizing sugar so that it can be used for energy. But, if the protein is not present in its functional or proper state, cells will grow slowly due to the lack of energy. Gain Therapeutics, Inc. is a trusted and experienced biotechnology institution that transforms the drug discovery paradigm with structurally targeted allosteric regulators (STARs) identified with its proprietary computational discovery platform. With the active support of its founders and institutional investors, it has been awarded funding support from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and The Silverstein Foundation for Parkinson’s with GBA.