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1. Electrolyte Emergencies
3. Hyponatremia Causes
Loss of salt and water
Diuretics
Addisons disease
Osmotic diuresis (DKA)
Vomiting
Diarrhea
Diaphoresis
4. Hyponatremia Causes
Increase in body water (dilutional hyponatremia)
Excess water intake (water intoxication)
CHF
Renal failure
Cirrhosis
5. Hyponatremia Signs/Symptoms
Lethargy, apathy secondary to cerebral edema
Headache
Muscle twitching, cramps
Seizures
Na+ < 110 mEq/L
6. Hyponatremia Treatment
NS infused at a rate to restore normal sodium over 48 hours
7. Hypernatremia Elevated serum sodium
Na+ >150 mEq/L
8. Hypernatremia Causes
Pure water loss
Diabetes insipidus
Pure solute gain
NaHCO3 administration
9. Hypernatremia Causes
Water loss > Solute loss
Diarrhea
Vomiting
Sweating
Osmotic diuresis
10. Hypernatremia Signs/Symptoms
Irritability, restlessness
Coma
Intracranial hemorrhage
Blood sludging - thrombosis
Seizures
Thirst, dry mucus membranes, poor skin turgor
11. Hypernatremia Treatment
Infusion of D5W (free water) to correct water deficit over 48 hours
12. Hypokalemia Decreased serum potassium
K+ < 3.5 mEq/L
13. Hypokalemia Causes
Gastrointestinal losses
Diarrhea
Vomiting
NG suction
Urinary losses
Diuretics
Osmotic diuresis
14. Hypokalemia Causes
Intracellular shifts
Alkalosis
? agents
Theophylline
Inadequate intake
15. Hypokalemia Signs/Symptoms
Weakness, hyporeflexia, paresthesias
Decreased GI motility
Nausea, vomiting
Increased sensitivity to digitalis
16. Hypokalemia Signs/Symptoms
EKG changes
Flat to inverted T waves
U waves
ST segment depression
Cardiac arrhythmias
Ventricular ectopy
V-Fib
17. Hypokalemia Treatment
Correct underlying cause
10 mEq KCL IV over 1 hour, repeated until serum K+ > 3.5 mEq/L
18. Hyperkalemia Elevated serum potassium
K+ > 5.5 mEq/L
K+ > 6 mEq/L - Emergency
K+ > 7 mEq/L - Life Threat
19. Hyperkalemia Causes
Decreased excretion
Renal failure
Addisons disease
? - blockers
Hyperglycemia
Acidosis
20. Hyperkalemia Causes
Increased intake
Crush injury, burns, sepsis
Massive hemolysis
Blood transfusion
High-dose penicillin
Increased oral intake
21. Hyperkalemia Signs/Symptoms
Muscle weakness
Numbness, tingling
EKG changes
Tall, peaked T waves
Broadening of QRS; decreased P wave size
Sine wave leading to V-Fib then asystole
22. Hyperkalemia Treatment
Calcium - 0.5 - 1.0g
Antagonizes cardiac toxicity
NaHCO3 - 50 mEq
Drives K+ into cells
D50W (25g)/insulin (10 units regular)
Drives K+ into cells
23. Hypocalcemia Decreased serum calcium
Ca2+ < 8.5 mg/100ml
24. Hypocalcemia Causes
Hypoparathyroidism
Vitamin D deficiency
Decreased dietary intake
Alkalosis
Massive blood transfusion
Citrate toxicity
25. Hypocalcemia Signs/Symptoms
Paresthesias
Hyperreflexia, carpopedal spasm, tetany
Seizures
Trousseaus sign:
Carpopedal spasm following BP cuff compression of arm
26. Hypocalcemia Signs/Symptoms
Chvosteks sign
Contraction of facial muscles when face is tapped at angle of jaw
Laryngospasms
Prolonged QT interval
Increased ventricular irritability
27. Hypocalcemia Management
Calcium chloride
1g over 10 - 20 minutes
Overly rapid administration of calcium can cause bradycardia, hypotension, and cardiac arrest
28. Hypercalcemia Increased serum calcium
Ca2+ > 10.5 mg/100ml
29. Hypercalcemia Causes
Malignancies
Skeletal, breast, lungs
Hyperparathyroidism
Vitamin D toxicity
Addisons disease
Milk/alkali syndrome
30. Hypercalcemia Signs/Symptoms
Apathy, fatigue, depression, coma
Muscle weakness
Hypertension
Anorexia, nausea, abdominal pain
31. Hypercalcemia Signs/Symptoms
Kidney stones
Short QT interval, heart block, cardiac arrest
Bones, Stones, Hypertones, Abdominal moans
32. Hypercalcemia Treatment
1 - 2 liters NS over 1 hour
Decrease Ca2+ reabsorption
Furosemide 40 mg IV
Inhibits Ca2+ reabsorption
Calcitonin
Directly lowers Ca2+