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Lopinavir/Ritonavir- A Promising Co-Formulated Drug

Lopinavir/ritonavir combination is the first and only coformulated HIV-1 protease inhibitor. Clinical trials have demonstrated lopinavir/ritonaviru2019s immunologic and virologic benefits of treatment of HIV-infected adults, adolescents, and children. Recently, studies revealed that a combination of Lopinaviru2013Ritonavir were proven effective against SARS-CoV and MERS-CoV, the previous two coronaviruses that hit the globe.

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Lopinavir/Ritonavir- A Promising Co-Formulated Drug

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  1. Lopinavir/Ritonavir- A Promising Co-Formulated Drug

  2. End of December 2019 and beginning of the year 2020 marked the emergence of, a novel coronavirus, designated SARS-CoV-2, and has caused an international outbreak of respiratory illness termed Covid-19. The full spectrum of Covid-19 ranges from mild, self-limiting respiratory tract illness to severe progressive pneumonia, multi-organ failure, and finally death.

  3. Although there is no therapeutic treatment for coronavirus agents till date but in a hopeful finding, studies revealed that a combination of Lopinavir–Ritonavir were proven effective against SARS-CoV and MERS-CoV, the previous two coronaviruses that hit the globe.

  4. Originally, Lopinavir/ritonavir combination is the first and only coformulated HIV-1 protease inhibitor. Clinical trials have demonstrated lopinavir/ritonavir’s immunologic and virologic benefits of treatment of HIV-infected adults, adolescents, and children.

  5. Recently a random, controlled, open-label trial for lopinavir–ritonavir (ritonavir helps to stabilize lopinavir) in 199 hospitalized patients with severe COVID-19 was conducted and the drug showed benefit for some secondary endpoints.Pharmaceutical parlance, medicinal fraternity and researchers are trying ways to find a promising treatment for the deadly virus. A lot of research is going on throughout the world and a lot of hard work, knowledge, infrastructure, technology and research material is required to find a cure for COVID -19.

  6. Some of the possible known and unknown impurities of Lopinavir required in clinical trials are tabulated below:

  7. Pharmaffiliates provides all the above-mentioned products for research and quality control purpose. In the critical time of pandemic, Pharmaffiliates assures to deliver on time and in a cost effective manner.We deliver all the research products with a Certificate of Analysis along with necessary data required to fulfill your regulatory needs.

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