1 / 31

Principles of Bioorganic Medicinal Chemistry Drugs & Medicinal Chemist

Principles of Bioorganic Medicinal Chemistry Drugs & Medicinal Chemist . Lovastatin-Mevacor. August 26/2002. Zbigniew J. Witczak, Ph.D. Principles of Bioorganic & Medicinal Chemistry PHA 598A: Dr. Zbigniew J. Witczak. Learning Objectives

Melvin
Download Presentation

Principles of Bioorganic Medicinal Chemistry Drugs & Medicinal Chemist

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Principles of Bioorganic Medicinal Chemistry Drugs & Medicinal Chemist Lovastatin-Mevacor August 26/2002. Zbigniew J. Witczak, Ph.D.

  2. Principles of Bioorganic & Medicinal Chemistry PHA 598A: Dr. Zbigniew J. Witczak Learning Objectives 1. Describe the mechanism by which cell macromolecules mediates the cellular response. 2. Identify the cell components and active macromolecules that are involved in the development and regulation of the cellular processes and drug action/response. 3. Identify the pharmacological responses by which the therapeutic agents acts in the multiple cellular system. 4. Identify the chemical aspects of drug action and their pharmacological responses.

  3. Clasification of Drugs • by pharmacological effect • by chemical structure • by target system • by site of action

  4. By pharmacological effect • analgesics • antipsychotics • antihypertensive • antiasmathics • antibiotics • anticonvulsant (sedative agents)

  5. By chemical structure • Opiates • Steroids • Barbiturates • Penicilins • Cateholamines Penicillin V

  6. Why should drugs work? • Cell/cell membranes • Where do drugs work? • Cell/cell membranes • Nucleus- “control centre” for the cell

  7. Molecular Targets in the Cell Affected by Drugs • Lipids • Proteins (Glycoproteins) • Nucleic acids

  8. Fatty acids and other lipids.

  9. Fatty acids and other lipids.

  10. Therapeutic Index ****** • Measure of the ratio of undesirable to desirable drug effects. • For in vivo systems thee therapeutics index could be the ratio of the LD50 ( the lethal dose for 50 % of the test animals) to the ED50 ( the effective dose that produces the maximum therapeutic effect in 50 % of the test animals. • The larger the therapeutic index the greater the margin of safety of the drug!!!!.

  11. Hydrophilic Hydrophilic Hydrophilic Hydrophobic Region Amphotericin B • Amphotericin B interacts with the lipids of fungal cell membranes • Build “Tunnels” through the membrane • The contents of the cell is drained away • Cell is killed

  12. Inhibitors of Glycosphingolipid Biosynthesis

More Related