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Anabolic-Androgenic Steroids

Anabolic-Androgenic Steroids. Anabolic: stimulate muscle growth Androgenic: stimulate male sex characteristics. Androstane. Male Sex Hormones. Before Castration. After Castration. It was deduced that a secretion of the testes was responsible for male sex characteristics.

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Anabolic-Androgenic Steroids

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  1. Anabolic-Androgenic Steroids Anabolic: stimulate muscle growth Androgenic: stimulate male sex characteristics

  2. Androstane

  3. Male Sex Hormones Before Castration After Castration • It was deduced that a secretion of the testes was responsible for male • sex characteristics

  4. Testis Extract and Hormones from Urine Testis extract: High activity

  5. Testosterone

  6. Separation of Androgenicand Anabolic Effects • Receptors for testosterone have the same affinity in the • sex accessory organs as in skeletal muscle

  7. Nandrolone

  8. Metabolic Deactivationof Testosterone

  9. 17α-substituted Derivatives

  10. 17β- Esters

  11. Structure Activity Relationship

  12. Performance Enhancers • 17α- alkyl and 17β- esters are not suitable for illegal use by athletes because of their prolonged life and ease of detection • Prohormones are metabolized into active anabolics and occur naturally in the body Androstenedione DHEA

  13. Side Effects

  14. References 1. Kochakian, C. D. “History of Anabolic-Androgenic Steroids.” Anabolic Steroid Abuse. 1990, 29-50. 2. Block, John H. Beale, John M. Organic Medicinal and Pharmaceutical Chemistry. Pa: Lippincott Williams and Wilkins. 2004. 3. Kochakian, C. D. “The Effects of Male Hormone on the Protein and Energy Metabolism of Castrate Dogs.” Journal of Nutrition. 1935. 437-59. 4. Bowers, A. Edwards, J. “Steroids: Ring A Modified Hormone Analogs, Part 1.” Journal of Medicinal Chemistry. 6. 1962. 5. Celotti, F. Cesi, P. “Anabolic Steroids: A review of their effects on the muscles, of their possible mechanisms of action and of their use in athletics.” Journal of Steroid Biochemistry and Molecular Biology. 43(5). 1992. 469-77. 6. Krieg, M. “Characterization of the androgen receptors in the muscle of the rat.” Steroids 28. 1976. 261-74. 7. Counsell, R. E. Adelstein, G. W. “!9-Nor- and 19-Substituted 5a-Androst-2-ene Derivatives” Journal of Medicinal Chemistry. 1966. 685-9. 8. Delbeke, Frans T. “Prohormones and Sport.” Journal of Steroid Biochemistry and Molecular Biology. 83. 2003. 245-51.

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