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Genetic and environmental contributions to monogenic and complex disorders. Manolio TA. J Clin Invest. 2008 May;118(5):1590-605. Breakdown of LD around a new SNP. Manolio TA. J Clin Invest. 2008 May;118(5):1590-605. Tag SNPs can define common haplotypes.
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Genetic and environmental contributions to monogenic and complex disorders Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.
Breakdown of LD around a new SNP Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.
Tag SNPs can define common haplotypes Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.
GWA studies in autoimmune and infectious diseases Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.
GWA studies in various traits Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.
GWA studies in various traits cont. Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.
Rationale for association studies Balding DJ. Nat Rev Genet. 2006 Oct;7(10):781-91.
Types of population association study Balding DJ. Nat Rev Genet. 2006 Oct;7(10):781-91.
Spurious associations due to population structure Balding DJ. Nat Rev Genet. 2006 Oct;7(10):781-91.
Log quantile–quantile (QQ) P-value plot for 3,478single-SNP tests of association Balding DJ. Nat Rev Genet. 2006 Oct;7(10):781-91.
Schematic representation of two significant haplotype blocks in KLRG1 gene in Asian adult SLE cohort
Association of FAIM SNPs with SLE in four racial groups and childhood- and adult-onset cases
The coefficients (Y-axis) for each individual across a multiethnic sample ordered by their self-identified ethnicity
Working model for genetic subtypes of SLE modeled on MHC Class II phenotype DR2 (non-Caucasian) DQw1 (Caucasian) Glomerulonephritis C4A null (normal genes) High anti-dsDNA Ab A1 B8 DR3 Ro, La Ab SICCA Syndrome C4A null (gene deletion) DR4 -ve assoc. Nephritis -ve assoc. anti-dsDNA Ab