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Genetic and environmental contributions to monogenic and complex disorders

Genetic and environmental contributions to monogenic and complex disorders. Manolio TA. J Clin Invest. 2008 May;118(5):1590-605. Breakdown of LD around a new SNP. Manolio TA. J Clin Invest. 2008 May;118(5):1590-605. Tag SNPs can define common haplotypes.

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Genetic and environmental contributions to monogenic and complex disorders

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  1. Genetic and environmental contributions to monogenic and complex disorders Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.

  2. Breakdown of LD around a new SNP Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.

  3. Tag SNPs can define common haplotypes Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.

  4. GWA studies in autoimmune and infectious diseases Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.

  5. GWA studies in various traits Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.

  6. GWA studies in various traits cont. Manolio TA. J Clin Invest. 2008 May;118(5):1590-605.

  7. Rationale for association studies Balding DJ. Nat Rev Genet. 2006 Oct;7(10):781-91.

  8. Types of population association study Balding DJ. Nat Rev Genet. 2006 Oct;7(10):781-91.

  9. Spurious associations due to population structure Balding DJ. Nat Rev Genet. 2006 Oct;7(10):781-91.

  10. Log quantile–quantile (QQ) P-value plot for 3,478single-SNP tests of association Balding DJ. Nat Rev Genet. 2006 Oct;7(10):781-91.

  11. KLRG1 haplotype blocks associated with SLE with p<0.05

  12. Schematic representation of two significant haplotype blocks in KLRG1 gene in Asian adult SLE cohort

  13. TNFSF4 haplotype blocks associated with SLE with p<0.05

  14. Association of FAIM SNPs with SLE in four racial groups and childhood- and adult-onset cases

  15. Gene maps in the vicinities of IRAK1, TLR8 and FAIM.

  16. Power calculation for SNP identification

  17. The coefficients (Y-axis) for each individual across a multiethnic sample ordered by their self-identified ethnicity

  18. Working model for genetic subtypes of SLE modeled on MHC Class II phenotype DR2 (non-Caucasian) DQw1 (Caucasian) Glomerulonephritis C4A null (normal genes) High anti-dsDNA Ab A1 B8 DR3 Ro, La Ab SICCA Syndrome C4A null (gene deletion) DR4 -ve assoc. Nephritis -ve assoc. anti-dsDNA Ab

  19. Power as a function of sample size

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