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Research strategy for RNOH-IOMS

Trust Board April 2008. Research strategy for RNOH-IOMS. David Marsh Professor of Clinical Orthopaedics Institute of Orthopaedics and Musculoskeletal Science, University College London Royal National Orthopaedic Hospital Stanmore, UK.

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Research strategy for RNOH-IOMS

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  1. Trust Board April 2008 Research strategy for RNOH-IOMS David Marsh Professor of Clinical Orthopaedics Institute of Orthopaedics and Musculoskeletal Science, University College London Royal National Orthopaedic HospitalStanmore, UK

  2. A joint IOMS-RNOH academic strategy is an essential part of the Outline Business Case • One of three stipulations in the letter from the SHA inviting submission:“set out a clear commitment to support the work of the university and its partners in achieving AHSC status and strengthening the Orthopaedic Institute”

  3. Academic Health Science Centre CLINICAL EXCELLENCE,INTEGRATION RESEARCH EDUCATION How are we going to fund this? • Joint Academic Plan: • integration of UG and PG education • R&D management into IOMS • Research strategy

  4. Research Strategy Health services research • Focused on musculoskeletal system but full spectrum Basic science Clinical trials Translational Experimental • Five themes, building on track record and patient needs • Innovative implant design • Cell therapy and tissue engineering • Disability and improvement of quality of life • Building the musculoskeletal evidence base • Sarcoma medicine

  5. Tapping in to UCL Health services research Musculoskeletal Consortium Basic science Clinical trials Translational Experimental • Five centres in IOMS • Bioengineering • Tissue engineering • Clinical academic • Rehabilitation • Pathology • Innovative implant design • Cell therapy and tissue engineering • Disability and improvement of quality of life • Building the musculoskeletal evidence base • Sarcoma medicine Engineering Centre for Ageing Cancer Institute

  6. Funding UKCC EPSRCBBSRC MRC NIHR Basic science Translational Experimental Clinical trials Health services research ARC, charities

  7. National Institute for Health Research - the new research environment • Concentration of funded clinical research in fewer, larger centres • Large research teams • Epidemiology, health economics vital • Many Trusts giving up and outsourcing research management • Competition with all other specialities - fierce • Priorities in cancer, neuro, endocrine, mental, children • Role of rheumatology • Research governance demands tighter Transform or fade out

  8. NIHR funding streams • Comprehensive biomedical research centresSpecialist BMRCsBiomedical Research Units • Musculoskeletal in Oxford, Sheffield, Leeds • Local Comprehensive Research Networks • HTA, RfPB, NEAT, RISC • Applied Research Programme Grants • Technology Support Board

  9. MRC Translational Research Call • £241m extra, most on translational research • Bottlenecks • Pan-UCL bid going in • MRC Centre for Cell and Gene Therapy • Stanmore hopefully to contribute cell therapy in the musculoskeletal system

  10. Cell-based therapy • Clinical trials in ACI • Preclinical work on bone, collagen • Regenerative Medical Systems - UK • Translational teams • Bone • Tendon • Cartilage

  11. Stanmore Clinical Research Facility • At present a joint venture between RNOHT and UCLB – may change • Goal is to facilitate rapid study design, costing, governance and conduct • Both investigator-led and commercial • All must be fully funded • Building a clinical research network is crucial • eg fragility fractures and drugs that enhance fracture healing

  12. Research pipeline in cell-based therapy Health services research Basic science Clinical trials Translational Experimental What phenotype of cultured cells produces the best clinical response? Is it cost-effective to culture-expand cells rather than use bone marrow? Can we design new way ways of efficiently expanding stem cells? IOMS RMS-UK SCRF

  13. Integrated Academic Training Programme • Four Academic Clinical Fellows • Two Clinical Lecturers

  14. UCL Dean and Research Vice-Provost Trust Board UCL and Partners Health Sciences Research Deanery Academic Research Board Research Governance Committee Education Committee Research Committee PPI group

  15. Research Support Staff • Academic Clinical Centre of IOMS • MRC Clinical Trial Unit support • Chair of Musculoskeletal Epidemiology • Alex MacGregor – starting Sep 08 • R&D Director and Manager (Joseph Datukasi) • Nerina – Head of Academic Business Development • SCRF staff • IT systems for research support – Simon Grange

  16. Research Governance • MHRA inspection • Duties of Principal Investigators • Duties of RNOH as a sponsor • Our IT solutions

  17. MHRA Inspection

  18. MHRA Inspection

  19. Support we can offer • Training • Executive GCP training • Research Pack • Best methodological practice in musculoskeletal research • Governance • Integration locally with Risk assessment • Integration with Local Comprehensive Research Network • Research • Finding Research Partnerships • Developing hypotheses and designing studies • Finding funding sources

  20. Research Governance

  21. Clinical Trials Support • Being tested by our iBSc & MSc students

  22. Electronic Patient Record

  23. Clinical Sen Lec MSK epidemiologist R&D Director R&D Manager Biostatistician Health economist 05 06 07 08 09 10 11 12 My tenure Team building IT/governance support Medical physics Joint academic strategy capacity building SCRF Regenerative Medical Systems - UK Multidisciplinary MSc Integrated Academic Training Programme

  24. 05 06 07 08 09 10 11 12 Expenditure NHS R&D UCL Grant targetoverheads, contributions to salary, SCRF profit MRC stem cells in nonunion 300k Pfizer fracture accelerating drug 500k TSB grant 500k NIHR Applied Research Programme £2m

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