Research: Plant protein replacing animal protein may extend lifespan

1. Recently, a research article was published in the top journal BMJ, which aims to evaluate and quantify the potential dose-response relationship between the intake of total, animal and plant protein and the risk of death from all causes, cardiovascular diseases and cancer. https://eu.echemi.com/ https://eu.echemi.com/ Researchers conducted a systematic review and meta-analysis of prospective cohort studies. As of December 2019, researchers have searched PubMed, Scopus and ISI Web of Science and the references of related articles retrieved, and selected to report the estimated risk of all-cause, cardiovascular disease and cancer mortality for adults over 18 Prospective cohort study. The random effects model was used to calculate the combined effect size and 95% confidence interval of the highest and lowest protein intake, and included the difference between studies. The researchers performed linear and non-linear dose-response analysis to assess the dose-response relationship between protein intake and mortality. Thirty-two prospective cohort studies were included in the systematic review, and 31 studies were included in the meta-analysis. During the follow-up period of 3.5 to 32 years, 113,039 deaths out of 715,128 participants (16,429 cases of cardiovascular disease, 22,303 cases of cancer). Total protein intake was associated with a lower risk of death from all causes (combined effect size was 0.94, 95% confidence interval was 0.89 to 0.99, I2=58.4%, P<0.001). Intake of plant protein and reduction of all-cause mortality (combined effect size is 0.92, 95% confidence interval is 0.87 to 0.97, I2=57.5%, P=0.003) and cardiovascular disease mortality (combined hazard ratio is 0.88, 95% The confidence interval is 0.80 to 0.96, I2=63.7%, P=0.001) is significantly correlated, but not related to cancer mortality. There is no significant correlation between the intake of total

2. protein and animal protein and the risk of cardiovascular disease and cancer mortality. Dose-response analysis showed that there was a significant negative dose-response correlation between the intake of plant protein and all-cause mortality (non-linear, P=0.05). Getting 3% extra energy from vegetable protein every day can reduce the risk of all-cause death by 5%. It can be seen that a higher total protein intake is related to a lower risk of all-cause death, while the intake of plant protein can reduce all-cause and cardiovascular disease mortality. Replacing foods high in animal protein with vegetable protein sources may extend lifespan.