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Rolv Skjærven MBRN, MoBa and UiB

Generational data The Medical Birth Registry of Norway (MBRN) and The Norwegian Mother and Child Study (MoBa). Rolv Skjærven MBRN, MoBa and UiB. MoBa-data: Mother’s and father’s year of birth: 1967 or later?. 83.5%. 94.3%. Father’s year of birth. Mother’s year of birth. Births in MoBa.

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Rolv Skjærven MBRN, MoBa and UiB

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  1. Generational dataThe Medical Birth Registry of Norway (MBRN) and The Norwegian Mother and Child Study (MoBa) Rolv Skjærven MBRN, MoBa and UiB

  2. MoBa-data: Mother’s and father’s year of birth: 1967 or later? 83.5% 94.3% Father’s year of birth Mother’s year of birth

  3. Births in MoBa 94% are born in 2002 or later Child’s year of birth

  4. MBRN N=668,433 N=537,178

  5. Generation dataand birth weight

  6. Reproduction for men and women, themselves born with low birthweight

  7. Publisert, 2008, Swamy, Østbye, Skjaerven, JAMA, 2008 - gestational age

  8. Birthweight and smoking (and education) Early origin to adult diseases, or confounding due to social factors? • (Birthweight and attained education) • Birthweight and smoking as an adult

  9. Perinatal birth and parental birthweight

  10. Perinatal death and parental birthweight and gestational age mothers fathers Nortveit, Melve, Skjaerven; PPE 2010

  11. Perinatal death in twins and singletons by maternal gestational age Tandberg, Melve, Nordtveit, Bjorge, Skjaerven; BJOG 2011

  12. Skjaerven et al.; BMJ 1997

  13. Are 1st births growth retarded? (published by Hypponen et al., 2004)

  14. Background 1) First born infants (rel. 2nd and later born infants) • have more often low birthweight (or preterm) • are more often small-for-gestational-age • have higher perinatal mortality 2) There is in general strong association between maternal and offspring birthweight

  15. Objective Is the reduced birthweight of 1st born mothers reflected in the offspring?

  16. Nordtveit, Melve, Skjaerven, 2009

  17. more examples...Breech deliveryMalformationsPreeclampsia

  18. Breech delivery • ”Inherited” as strongly from the father (OR=2.2) as from the mother (OR=2.2) Nordtveit, Melve, Albrechtsen, Skjaerven, BMJ, 2008

  19. Malformations • Recurrence of malformations through generations • (Recurrence of malformations between sibling)

  20. Recurrenc of malformations between generations • Focus the recurrence of similar or dissimilar defects (25 categories of defects) • Published: • Sibling recurrence (Lie, Wilcox, Skjaerven;NEJM, 1994) • Malformations, mother to offspring (Skjaerven, Wilcox, Lie; NEJM, 1999) • Malformations, father to offspring (Lie, Wilcox, Skjaerven; JAMA, 2001)

  21. Recurrence of malformations: siblings and generations Recurrence Risks (OR) Total Same Different • 1st to 2nd siblings: 2.5 7.6 1.7 • mother to offspring: 1.6 6.8 1.0 • father to offspring: 2.4 6.5 1.8 Attributable risks: • Affected mothers contribute to 5 out of 1000 registered birth defects in the next generation • Affected fathers contribute to 16 out of 1000

  22. Survival of females with birth defects, compared to females without birth defects

  23. Gestational age and generations • Magnus, Bakketeig, Skjaerven; 1993 “…low correlation between mother and offspring, r=0.086” • Lie, Wilcox,Skjaerven, 2006 ”... a fetal component that is heritable” • Wilcox, Lie, Skjaerven, 2008 ”... paternal genes have little, if any, effect on preterm delivery risk. This argues against major contributions of fetal genes inherited from either parent. The increased risk of preterm delivery among mothers born preterm is consistent with heritable maternal phenotypes that confer a propensity to deliver preterm”

  24. Preeclampsia between generations(Skjaerven et al., BMJ, 2005) • Preeclampsia recurrence • From mother to offspring • From fathers to offspring • From unaffected sisters? • From unaffected brothers? • Independent effect of maternal and paternal birthweight? • Does the reduced birthweight of preeclampsia cases in the 1st generation give reduced birthweight also in the next generation?

  25. Figure 1. Risk for preeclampsia in the second generation, given a preeclamptic pregnancy in the first generation. (Shaded area represents preeclamptic pregnancies.)

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