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Agents for Infections Due to Gram Positive Bacteria

Sorting Out Antibiotics: A systematic approach to antibiotic selection Kenneth Alexander, M.D., Ph.D. Associate Professor of Pediatrics and Microbiology Duke University Medical Center Durham, North Carolina kenneth.alexander@duke.edu Streptococci (Group A and Group B) Pseudomonas aeruginosa

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Agents for Infections Due to Gram Positive Bacteria

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  1. Sorting Out Antibiotics:A systematic approach to antibiotic selectionKenneth Alexander, M.D., Ph.D.Associate Professor of Pediatrics and MicrobiologyDuke University Medical CenterDurham, North Carolinakenneth.alexander@duke.edu

  2. Streptococci (Group A and Group B) Pseudomonas aeruginosa Staph. epidermidis Staph. aureus MRSA RGNR GNR Penicillin G Penicillin V Vancomycin Agents for Infections Due to Gram Positive Bacteria Methicillin, Oxacillin, Nafcillin, Cloxacillin Dicloxacillin, Cloxacillin Dalfopristin/Quinopristin, Linezolid, Daptomycin Linezolid

  3. Broad and Extended Spectrum Penicillins Streptococci (Group A and Group B) Pseudomonas aeruginosa Staph. epidermidis Staph. aureus MRSA RGNR GNR Ampicillin Amoxicillin Carbenicillin, Mezlocillin, Piperacillin, Ticarcillin Ampicillin + Sulbactam = Unasyn® Amoxicillin + Clavulanic Acid = Augmentin® Ticarcillin + Clavulanic Acid = Timentin ®, Piperacillin + Tazobactam = Zosyn®

  4. Cephalosporins Streptococci (Group A and Group B) Pseudomonas aeruginosa Staph. epidermidis Staph. aureus MRSA RGNR GNR Cefuroxime, Cefoxitin Cefaclor, Loracarbef, Ceftibuten Cefprozil, Cefuroxime axetil, Cefpodoxime, Cefdinir Ceftriaxone, Cefotaxime Cefixime Ceftazidime Cefazolin 1st Generation Cephalexin, Cefadroxil 2nd Generation 3rd Generation Cefepime 4th Generation

  5. Macrolides, Azalides and Ketolides Streptococci (Group A and Group B) Pseudomonas aeruginosa Staph. epidermidis Staph. aureus MRSA RGNR GNR Erythromycin Erythromycin Azithromycin Clarithromycin, Azithromycin, Telithromycin

  6. Broad Spectrum Antibiotics Streptococci (Group A and Group B) Pseudomonas aeruginosa Staph. epidermidis Staph. aureus MRSA RGNR GNR Ciprofloxacin, Levofloxacin, Moxifloxacin, Gatifloxacin Ciprofloxacin, Levofloxacin, Moxifloxacin, Gatifloxicin Gentamicin, Tobramycin, Netilmicin, Amikacin Trimethoprim/Sulfamethoxazole Trimethoprim/Sulfamethoxazole Tetracycline, Doxycycline, Minocycline Tetracycline, Doxycycline, Minocycline, Tigecycline Imipenem, Meropenem, Ertapenem

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