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This chapter provides an overview of the major classes of drugs, including their common names, therapeutic uses, adverse effects, and special precautions. It covers drugs for the nervous system, cardiovascular system, respiratory system, musculoskeletal system, endocrine system, immune system, gastrointestinal system, urinary system, women's and men's health, anti-infectives, antiviral agents, antifungal agents, hematologic and oncologic agents, and nutritional and dietary supplements.
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Foundation Knowledge and Skills Chapter 10: Drug Classification and Pharmacologic Actions
Learning Outcomes • For major classes of drugs: • Identify common drug names for each classification • Describe actions- therapeutic uses • Describe most common or most serious adverse effects • List special precautions
Key Terms • Agranulocytosis • Antiproliferative • Arthralgia • Cross-sensitivity • Expectorate • Myalgia • Myelosuppression • Peripheral neuropathy • Rhinitis
Section 1: Body Systems
Drugs for Nervous System • Antiepileptic Agents • Parkinsonian Agents • Alzheimer’s Disease Agents • Multiple Sclerosis Agents • Drugs to Treat Headaches/Migraines • Drugs to Treat Neuropathic Pain • Drugs to Treat Mood Disorders • Antidepressants
Drugs for Nervous System • Tricyclic Antidepressants • Monoamine Oxidase Inhibitors (MAO-I) • Selective Serotonin Reuptake Inhibitors (SSRIs) • Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) • Miscellaneous Agents • Drugs for Bipolar Disorder • Anti-Anxiety Agents (Anxiolytics) • Antipsychotic Agents
Drugs for Nervous System • Sedatives & Hypnotics • Drugs to Treat Attention Deficit Hyperactivity Disorder (ADHD)
Cardiovascular System Drugs • Cholesterol-lowering Agents • HMG-CoA Reductase Inhibitors • Bile Acid Sequestrants • Fibrates • Other Lipid-lowering Agents • High Blood Pressure Agents (Antihypertensives) • Diuretics • Beta-blockers
Cardiovascular System Drugs • ACE Inhibitors (ACEs) • Angiotensin Receptor Blockers (ARBs) • Calcium Channel Blockers • Vasodilators • Nitrates • Digoxin • Antiarrhythmics
Respiratory System Drugs • Bronchodilators • Corticosteroids • Other Agents for Treating Asthma • Cough and Cold Products
Musculoskeletal System Drugs • Osteoporosis Agents • Anti-Inflammatory Agents • Skeletal Muscle Relaxants • Analgesics
Endocrine System Drugs • Insulin • Oral Antidiabetic Agents • Thyroid Agents
Immune System Drugs • Antihistamines • Nasal Corticosteroids • Vaccines
Gastrointestinal System Drugs • Antacids • Histamine-2 Receptor Antagonists • Proton Pump Inhibitors • Anti-Nausea (Antiemetic) Agents • Agents to Treat Inflammatory Bowel Disease (IBD) • Antidiarrheals • Laxatives
Urinary System Drugs • Overactive Bladder Agents
Other Body Systems Drugs • Ophthalmics • Medications for Treating Conjunctivitis • Medications for Treating Glaucoma • Medications for Treating Dry Eyes • Otics • Topical Agents
Section 2: Women’s and Men’s Health
Women’s Health Drugs • Contraceptives • Fertility Agents • Hormone Replacement Therapy
Men’s Health Drugs • Medications to Treat Benign Prostatic Hypertrophy (BPH) • Medications to Treat Erectile Dysfunction (ED)
Section 3: Anti-Infectives
Antibiotics • Beta-lactam Antibiotics • Penicillins • Cephalosporins • Carbapenems & Monobactams
Antibiotics • Macrolides • Sulfonamides • Tetracyclines • Aminoglycosides • Fluoroquinolones • Clindamycin • Metronidazole • Vancomycin • Antitubercular Drugs
Antiviral Agents • Herpes viruses • acyclovir (Zovirax), famciclovir (Famvir), valaciclovir (Valtrex) • Influenza A & B • oseltamivir (Tamiflu) • zanamivir (Relenza) • Respiratory syncytial virus (RSV) • ribavirin (Virazole) • Palivizumab (Synagis)
Antiviral Agents for HIV • Human immunodeficiency virus (HIV) AIDS • Nucleoside reverse transcriptase inhibitor (NRTI) • zidovudine (Retrovir), emtricitabine, didanosine, lamivudine • Protease inhibitors • Indinavir (Crixivan) • Non-nucleoside reverse transcriptase inhibitors • (NNRTI) • nevirapine (Viramune)
Antiviral Agents for CMV • Cytomegalovirus (CMV) • ganciclovir (Cytovene) • foscarnet (Foscavir)
Antifungal Agents • Amphotericin available in multiple formulations: • conventional • liposomal (AmBisome) • lipid complex (Abelcet) • colloidal lipid dispersion (Amphotec) • Azole antifungals • ketoconazole (Nizoral) • fluconazole (Diflcan) • itraconazole (Sporanox) • posaconazole (Noxafil) • voriconazole Vfend)
Antifungal Agents • Echinocandins • caspofungin (Cancidas) • micafungin (Mycamine) • anidulafungin (Eraxis)
Section 4: Hematologic andOncologic Agents
Hematologic System Drugs • Blood Products • Anticoagulants and Thrombolytics • Thrombolytics
Chemo Classifications • Alkylating Agents • Antibiotics • Antimetabolites • Aromatase Inhibitors • Biologic Response Modifiers • Heavy Metal Compounds (Platinums) • Hormones • Immunomodulators
Chemo Classifications • Microtubule-targeting agents • Mitotic Inhibitors • Monoclonal Antibodies • Retinoids • Selective Estrogen Receptor Modulators (SERMs) • Topoisomerase Inhibitors • Tyrosine Kinase Inhibitors • Misc Agents
Section 5: Nutritional andDietary Supplements
Vitamins • Involved in cellular chemical reactions & essential to • normal tissue growth • maintenance & function • Vitamin D-synthesized by body with sunlight • all other essential vitamins from diet • Recommended dietary allowance (RDA) • Fat-soluble or water- soluble • fat-soluble vitamins : A,D,E, K
Vitamin Synonyms • Vitamin A = Retinol • Vitamin E = Tocopherol • Vitamin B 1 = Thiamine • Vitamin B 2 = Riboflavin • Vitamin B 5 = Pantothenic Acid • Vitamin B 6 = Pyridoxine • Vitamin B 12 = Cyanocobalamin • Vitamin B 3 = Niacin = Nicotinic Acid
Minerals • Constituents of enzymes, hormones, vitamins • Essential to • muscle contraction • nerve conduction • water and acid balance • Present in body in larger amounts • calcium, phosphorus, potassium, chloride, magnesium, sulfur • Trace elements • iron, zinc, iodine, chromium, selenium, fluoride, copper, manganese
Minerals • 4 minerals administered as single entities • calcium • iron • potassium • magnesium
Other Dietary Supplements • Complementary alternative medicine (CAM) • Incorrect belief that natural=safe • 36% of the population uses CAM • Immune system modulators (Echinacea) • Energy vitality CAM (ginseng, caffeine) • Weight loss CAM (caffeine, ginseng, bitter orange) • Women’s health CAM (calcium, soy) • Depression CAM (St. John’s Wort) • Bone/joint CAM (glucosamine/chondroitin)