Rationale

1. Rationale • Need a solid base for analysis of future genomes • Reference genome criteria: • Sequenced genome • MOD • Functional genomics projects • Adequate research community • Sufficient Literature base

2. Provide broad and deep annotations for reference genomes: • Work with reference genome MODs. They have agreed: • To use priorities set by GO • disease relevant genes • genes with human orthologs • provide data for metrics Reference Genome Annotation

3. Reference Genome Annotation • GO funded curators will coordinate the work at the MOD where they reside. They will also spend some time involved in assessing or annotating human genes when annotating orthologs in their organism • Provide outreach and training to non-reference genomes

4. Reference Genome Annotation • Participate in annotation consistency exercises. • Review GOA annotations for their organisms. This requires a bi-directional process with MODs reviewing GOA annotations and GOA reviewing human annotations performed by the GO annotation team.

5. Mouse/Human Rat as a Model for Coordinating Annotations across Species

6. Develop metrics to assess both breadth and depth. • Breadth • what % of genes are annotated with experimental data from that organism • what % of genes are annotated with ISS annotations (not otherwise annotated) • what % of genes are annotated with IEAs • goal is to maximize total coverage and experimental supported annotation

7. Develop Metrics to Assess Breadth and Depth of Annotation • Depth • % of papers used for curation • average # of papers per curated gene • can we capture the # of relevant papers since we know it is a subset of all papers. How?

8. Ontology Based Tree metrics

9. How to coordinate this annotation effort • Need process to set priorities • Need to develop list of “disease genes” and process to monitor progress. • Need to refocus and integrate roles of GO funded annotators • Need to establish coordination of GO Annotation Team. Fortnightly phone conferences.