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DEVELOPMENT OF CONNECTIVE TISSUE

DEVELOPMENT OF CONNECTIVE TISSUE. Mesenchyme. Loose Connective Tissue. Fibers. Fibroblasts. Mesenchymal. Cells. Cell Lineage from Mesenchymal Cells. TYPES OF CONNECTIVE TISSUE. Loose Connective. Dense Irregular. Dense Regular. Tissue. Connective Tissue. Connective Tissue.

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DEVELOPMENT OF CONNECTIVE TISSUE

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  1. DEVELOPMENT OF CONNECTIVE TISSUE Mesenchyme Loose Connective Tissue Fibers Fibroblasts Mesenchymal Cells

  2. Cell Lineage from Mesenchymal Cells

  3. TYPES OF CONNECTIVE TISSUE Loose Connective Dense Irregular Dense Regular Tissue Connective Tissue Connective Tissue (e.i. tendons, ligaments, (e.i. mesentery, omentum) (e.i. dermis of skin) cornea)

  4. DENSE IRREGULAR CONNECTIVE TISSUE (DERMIS OF SKIN)

  5. DENSE REGULAR CONNECTIVE TISSUE Tendon (longitudinal Section) Tendon (tranverse Section)

  6. ELASTIC CONNECTIVE TISSUE IN BLOOD VESSEL WALL Internal elastic lamina

  7. CONNECTIVE TISSUE FIBERS Collagenous Fibers Reticular Fibers Elastic Fibers (bundles) (networks) (anastomosing bundles)

  8. RETICULAR CONNECTIVE TISSUE reticular fibers (argyrophilic)

  9. COLLAGEN Fiber Fibril Microfibril FIBER Periodic Bands BUNDLE Tropocollagen alpha 1 peptide alpha 2 peptide SEM of Collagen Fibers TEM of Collagen Fibers

  10. SCANNING EM OF COLLAGEN FIBER BUNDLES

  11. TEM of Fibroblast and Collagen Bundles FIBROBLAST collagen fiber RER bundles procollagen tropocollagen Collagen Types I - skin, bone, tendon cornea (most common type) II- cartilage, embryonic cornea ground III- reticular fibers, loose c.t., blood vessel walls, dermis substance IV- basal lamina of epithelium (mucopolysaccharide) (no fibers, mat of randomly-oriented molecules)

  12. TEM OF FIBROBLAST WITH COLLAGEN BUNDLES

  13. FIXED CONNECTIVE TISSUE CELL TYPES Adipocytes Fibroblast (fat storage) (fiber producing cell) Fixed Macrophage Fibrocyte (histiocyte) (mesenchymal- pluropotent)

  14. Fixed Connective Tissue Cells Macrophage (light micrograph) Adipocytes fibroblast TEM of Macrophage

  15. MONONUCLEAR PHAGOCYTIC SYSTEM (reticuloendothelial system) Giant Cell Monocyte Mononuclear coalescence wandering cell Microglial Sinusoidal Macrophages Osteoclasts Kupffer Cells Cells Endothelia spleen liver bone liver central lymph nodes spleen sinusoids nervous resorption marrow bone marrow system connective tissue lung ( all characterized by phagocytic activity) serous cavities

  16. LYMPHOCYTES AND PLASMA CELLS (Agents of the immune response) (produce immunoglobulins Lymphocytes Plasma Cells -antibodies) differentiation stimulated by immune activation

  17. EOSINOPHILES MAST CELLS Secretion Products: 1. Slow-reaction substance of anaphalaxis actively phagocytic 2. Heparin- anticoagulant destroy immune complexes (antigen-antibody) 3. Histamine- stimulates inflammation 4. Serotonin- vasoconstrictor 5. Eosinophil Chemotactic Factor

  18. Connective Tissue Cells Plasma Cell Lymphocyte Macrophage

  19. TRANSMISSION EM OF AN EOSINOPHILE

  20. TRANSMISSION EM OF A MAST CELL

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