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Infectious Diseases Unit 4 Lesson 4 plan

Infectious Diseases Unit 4 Lesson 4 plan. Do now. What are the two ways a pathogen causes damage?. Do now. What are the two ways a pathogen causes damage? Direct Indirect. Do now. What are the two ways a pathogen causes damage? Direct Indirect

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Infectious Diseases Unit 4 Lesson 4 plan

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  1. Infectious Diseases • Unit 4 Lesson 4 plan

  2. Do now • What are the two ways a pathogen causes damage?

  3. Do now • What are the two ways a pathogen causes damage? • Direct • Indirect

  4. Do now • What are the two ways a pathogen causes damage? • Direct • Indirect • What feature do both types of damage have in common?

  5. Do now • What are the two ways a pathogen causes damage? • Direct • Indirect • What feature do both types of damage have in common? • They cause host cell lysis

  6. Do now • How do you think a virus causes damage to the host?

  7. Discussion • How viruses make us sick.

  8. The viral lifecycle has three stages: The virus needs to enter the cell The virus needs to replicate The virus needs to exit the cell

  9. How viruses make us sick Key goal Make more virus!

  10. Remember a virus needs to enter the cell: First the virus attaches to the cell it is going to infect. Then the virusenters the cell. Surface receptors of HINI

  11. Viral replication • RNA viruses • DNA viruses

  12. Before we can learn how viruses replicate we need to remember molecular dogma! DNA RNA Protein

  13. Before we can learn how viruses replicate we need to remember molecular dogma! DNA RNA Protein Replication Transcription Translation Where in the cell do these processes take place?

  14. Before we can learnhow viruses replicate we need to remember molecular dogma!

  15. DNARNAPROTEIN DNA viruses follow molecular dogma They need to get their DNA into the nucleus Herpesvirus is a DNA virus

  16. DNARNAPROTEIN DNA Viruses need host proteins to replicate Herpesvirus is a DNA virus

  17. RNARNAPROTEIN RNA viruses defy molecular dogma by makingRNAfrom RNA To do this they bring specialized enzymes with them H1N1 RNA viruses bring this enzyme with them

  18. RNADNARNAPROTEIN Retroviruses like HIV are RNA viruses They defy molecular dogma! They make DNA from RNA

  19. RNADNARNAPROTEIN Retroviruses defy molecular dogma by making DNA from RNA To do this they bring specialized enzymes with them Retroviruses bring the reverse transcriptase enzyme with them. They use an integrase, to insert the DNA into the host genome.

  20. RNA viruses cannot correct errors Random uncorrected mutations in RNA viruses cause Antigenic Drift

  21. Exit strategies • Can you remember the exit strategies for: • Naked viruses? • Enveloped viruses?

  22. Wrap up • Recap!

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