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Discovery of 4 common SNPs in the human tyrosine hydroxylase (TH) proximal promoter

Discovery of 4 common SNPs in the human tyrosine hydroxylase (TH) proximal promoter. G-801C. C-824T. G-494A. A-581G.

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Discovery of 4 common SNPs in the human tyrosine hydroxylase (TH) proximal promoter

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  1. Discovery of 4 common SNPs in the human tyrosine hydroxylase (TH) proximal promoter G-801C C-824T G-494A A-581G Figure 1. Discovery of four common SNPs (with flanking sequences) in the human tyrosine hydroxylase (TH) proximal promoter. A, C-824T (C/C C/T, T/T); B, G-801C (G/G, G/C, C/C); C, A-581G (A/A, A/G, G/G); D, G-494A (G/G, G/A, A/A). Red arrows indicate the SNP positions. Results are ABI-3100 sequence tracings analyzed in PolyPhred. Online I

  2. Online II

  3. Human tyrosine hydroxylase (TH) promoter:Graphical Observation of Linkage Disequilibrium (“GOLD”).4 common SNPs (minor allele freq. 0.119-0.454) spanning 331 bp. D’ D’ Promoter position 5’ of ATG Results by Lian Zhang in n=293 unrelated individuals of four different ancestries. 1-3-05. Online IIIA

  4. Human tyrosine hydroxylase (TH) promoter:Graphical Observation of Linkage Disequilibrium (“GOLD”).4 common SNPs (minor allele freq. 0.119-0.484) spanning 331 bp. D’ D’ D’ Promoter position 5’ of ATG Results by Lian Zhang in n=189 unrelated individuals of European ancestry. 1-3-05. Online IIIB

  5. Human tyrosine hydroxylase (TH) promoter:Graphical Observation of Linkage Disequilibrium (“GOLD”).4 common SNPs (minor allele freq. 0.100-0.283) spanning 331 bp. D’ D’ Promoter position 5’ of ATG Results by Lian Zhang in n=30 unrelated individuals of Asian ancestry. 1-3-05 Online IIIC

  6. Human tyrosine hydroxylase (TH) promoter:Graphical Observation of Linkage Disequilibrium (“GOLD”).4 common SNPs (minor allele freq. 0.171-0.471) spanning 331 bp. Results by Lian Zhang in n=35 unrelated individuals of Hispanic ancestry. 1-3-05. D’ Promoter position 5’ of ATG Online IIID

  7. Human tyrosine hydroxylase (TH) promoter:Graphical Observation of Linkage Disequilibrium (“GOLD”).4 common SNPs (minor allele freq. 0.090-0.410) spanning 331 bp. Results by Lian Zhang in n=39 unrelated individuals of African ancestry. 1-3-05. D’ Promoter position 5’ of ATG Online IIIE

  8. Baroreceptor slope: Downward versus upward deflections. Online IVA

  9. TH pleiotropy. Baroreceptor sensitivity as a determinant of basal norepinephrine release. Stratification by TH promoter haplotype 2. Downward deflections. Online IVB

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