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Nondisjunction disorders

Nondisjunction disorders. And other abnormal chromosome events. Human male karyotype, written as 46 XY. Human female karyotype, written as 46 XX. Jacob’s Syndrome. 1 in 1,800 births 47 chromosomes XYY only 47XYY #23 Trisomy Nondisjunction. Jacob’s syndrome. XYY

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Nondisjunction disorders

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  1. Nondisjunction disorders And other abnormal chromosome events

  2. Human male karyotype, written as 46 XY

  3. Human female karyotype, written as 46 XX

  4. Jacob’s Syndrome 1 in 1,800 births 47 chromosomesXYY only 47XYY #23 Trisomy Nondisjunction

  5. Jacob’s syndrome • XYY • No abnormal appearance/behavior • fertile

  6. Klinefelter’sSyndrome 1 in 1,100 births 47 chromosomesXXY only 47, XXY #23 Trisomy Nondisjunction

  7. Klinefelter’s Syndrome • XXY, male

  8. Klinefelter’sSyndrome Scarce beard Longer fingers and arms Sterile Delicate skin Low mental ability Normal lifespan

  9. Triple X Syndrome 1 in 2,500 births 47 chromosomesXXX only #23 TrisomyNondisjunction

  10. Triple X Syndrome Normal physically Normal mentally Fertile

  11. Patau’s Trisomy Syndrome 1 in 14,000 births 47 chromosomesXY or XX 47, +13 #13 Trisomy Nondisjunction

  12. Patau’sTrisomy Syndrome Small head Small or missing eyes Heart defects Extra fingers Abnormal genitalia Mentally retarded Cleft palate Most die a few weeks after birth

  13. Down Syndrome 1 in 1,250 births 47 chromosomesXY or XX #21 Trisomy Nondisjunction

  14. Down Syndrome • 47, XY, +21

  15. Down Syndrome Short, broad hands Stubby fingers Rough skin Impotency in males Mentally retarded Small round face Protruding tongue Short lifespan

  16. Down Syndrome 1 in 4,400 births47 chromosomes XX=80% XY=20% #18 Trisomy Nondisjunction

  17. 47, XY, +18 Edward’s Trisomy Syndrome Small head Mentally retarded Internal organ abnormalities 90% die before 5 months of age 47, XY, +18

  18. Turners Syndrome • 45, X

  19. Turners Syndrome 96-98% do not survive to birth No menstruation No breast development No hips Broad shoulders and neck

  20. Prader-Willi Syndrome 1 in 5,000,000 births46 chromosomes XY=97% XX=3% #15 Deletion of lower arm

  21. Prader-Willi Syndrome Small bird-like head Mentally retarded Respiratory problems Obesity Short lifespan

  22. Cat-Eye Syndrome 1 in 1,000,000 births 46 chromosomesXY or XX #22 Deletion of bottom arm

  23. Cat-Eye Syndrome Fused fingers and toes Mentally retarded Small jaw Heart problems Normal lifespan

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