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Research in Genetics

Research in Genetics. Dr. Helena Seth-Smith G and L 1987-1994 Wellcome Trust Sanger Institute Cambridge. What I’ll talk about. Science as a career Career structure in science My Ph.D. project The Sanger Institute A day in the life... Questions. Science as a career. Science as a Career.

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Research in Genetics

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  1. Research in Genetics Dr. Helena Seth-Smith G and L 1987-1994 Wellcome Trust Sanger Institute Cambridge

  2. What I’ll talk about... • Science as a career • Career structure in science • My Ph.D. project • The Sanger Institute • A day in the life... • Questions

  3. Science as a career

  4. Science as a Career

  5. Interesting

  6. Use your brain

  7. Continue learning

  8. Discover the unknown, and pursue it

  9. Expert in your field

  10. Freedom of research

  11. Flexible work

  12. Variety within work

  13. Active

  14. Not a traditional job for life

  15. You can travel with jobs

  16. You can travel with conferences

  17. South Africa - Kruger

  18. Zimbabwe – Victoria Falls

  19. South Africa – Cape Town

  20. Puerto Rico

  21. Young and varied people - casual

  22. Further personal development

  23. You don’t do it for the money

  24. Science has geeks

  25. But other professions have issues too

  26. Career structure in science

  27. Career Structure in Science(not that you have to decide early on) Undergraduate degree Postdoctoral position (Professorship) Ph.D. Lectureship Second postdoc...

  28. Undergraduate degree • Natural Sciences for choice of subjects • Format: lectures and practicals • First year: cell biology, physiology, chemistry, maths • Second year: molecular cell biology, biochemistry, • history and philosophy of science • Third year: Genetics • Can lead to a number of careers • Need 2.1 or above for PhD

  29. Ph.D. • Format: research (papers and lab work) • Choose a subject you are interested in • Autonomy : planning • Social life, sport, teaching ... • Produce a MAJOR piece of work (STRESS!!) • Useful skills for other jobs

  30. Postdoctoral position • Continue in same field or choose to learn another • Location, location, location • 2-3 years to do publishable research

  31. Second postdoc... • Ditto • And maybe ditto again • Find your own niche / area of interest • Or move into industrial science

  32. Lectureship • Own research group and teaching • Permanent post • More permanent location • Fewer women

  33. (Professorship) • Highest level in academia • Head of Department

  34. My Ph.D. Project:Microbial Degradation of RDX

  35. Bacteria eating explosives

  36. Explosives are dangerous... ...to our health

  37. Explosive polluted sites

  38. TNT Trinitro- toluene RDX Royal demolition explosive Explosives in bombs

  39. Seeing bacteria eating explosives Where RDX has been eaten and removed, agar is clear RDX makes the agar on the plate look white and grainy

  40. Up close and personal 5mm (Electron microscopes don’t show orange!)

  41. Growth curve

  42. The gene I discovered Gene..... makes... Protein

  43. Gene in plants Normal, wild type plants - get sicker as they are grown with more explosive Plants with my gene in - healthy when grown with explosive more explosive in the soil

  44. The future

  45. The Wellcome Trust Sanger Institute www.sanger.ac.uk

  46. The Sanger Institute AIM: To sequence and analyse genomes, for future research on human biology and disease

  47. Organisms with Sequenced Genomes

  48. From organism to DNA...

  49. ...to sequence

  50. A day in the life...

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