Total Synthesis of Cribrostatin IV and ET-743

Sep 19, 2014

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Total Synthesis of Cribrostatin IV and ET-743. Literature Meeting Presented by Nancy Labbé-Giguère January 30 th , 2006 Danishefvsky, S. et al , J. Am. Chem. Soc. 2005 , 127 , 4596-4598. D-amino acid. What is the structure of Fremy Salt? Mechanism of the reaction?. X.

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selective oxidation
substrate unstable
literature meeting
mildly basic conditions
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Total Synthesis of Cribrostatin IV and ET-743

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Total Synthesis of Cribrostatin IV and ET-743 Literature Meeting Presented by Nancy Labbé-Giguère January 30th, 2006 Danishefvsky, S. et al, J. Am. Chem. Soc.2005, 127, 4596-4598.

D-amino acid

What is the structure of Fremy Salt? Mechanism of the reaction?

X • Substrate unstable to mildly basic conditions. • - Ketone was attacked by nucleophile. Cleavage of the β-dicarbonyl bond was observed.

PIFA ?? For the selective oxidation of ring A, see: Conant, J. B.; Fieser, L. F. J. Am. Chem. Soc.1924, 46, 1858.

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