National Pharmacology Quiz 2011

1. National Pharmacology Quiz 2011

2. Round 3 Cover story & Movies

3. Rules for Round 3 • This round has two parts: Part 1 – Cover story, Part 2 – Movies. • Every team will get one question in each part. • You have 30 seconds to answer each question. • Ten points for answering correctly. No negative marks for wrong answer. • Unanswered / wrongly answered questions pass to the next team. You get 5 seconds to answer it and five points for answering correctly.

4. Round 3 – Part I Cover Story

5. Team C What is the cover page illustration of Basic & Clinical Pharmacology, 11th edition?

6. Answer The interaction of fluvastatin with its target, the catalytic site of the enzyme HMG-CoAreductase

7. Team D This is the cover page of Oct 2, 2010 issue of British Medical Journal. This illustration is about a drug to increase female sexual desire. Name this drug. BMJ A pill for low libido in women HOPE OR HYPE?

8. Answer Flibanserin which reduces serotonin concentrations while raising those of dopamine and noradrenaline

9. Team A This is the cover page of November 2011 issue of Clinical Pharmacology & Therapeutics. Identify this person.

10. Answer The person depicted is Dr. James Lind He was the first person to conduct a clinical trial. He compared the effect of six different food supplements on scurvy.

11. Team B This is the cover page of July 18, 2009 issue of British Medical Journal. This illustration is about assisted dying of critically ill patients. Assisted dying is legal in Switzerland . Three other countries have also made it legal. Name any two among them.

12. Answer Netherlands – 2001 Belgium – 2002 Luxembourg - 2009

13. Round 3 – Part II Movies

14. Team B Paul Ehrlich is known as the father of chemotherapy. His life history was made as a film. Name this film.

15. Answer Magic Bullet

16. Team A The constant Gardener, a love story set against a conspiracy. Ralph Fiennes unfolds the mystery of his wife’s death. He runs against a drug company that’s using Africans for testing a drug with known adverse effects. Name the drug which inspired the film .

17. Answer Trovafloxacin

18. Team D This film is based on a real story in which the parents of a child affected by adrenoleukodystrophy find a drug to prevent demyelination. Even though doctors predicted the child will die at 2 years of age he lived because of the drug for up to 30 years and died recently (2008). Name this film.

19. Answer Lorenzo’s Oil

20. Team C This interactive movie produced by United States Office of Research Integrity (ORI) is about research integrity, handling of data and mentorship responsibilities. This movie was released recently (2011). Name this movie.

21. Answer The Lab

22. Round 4 Back to School

23. Rules for Round 4 • This round has two parts: Part 1 – Alphabets, Part 2 – Numbers. • Every team will get two questions in each part. • You have 30 seconds to answer each question. • Ten points for answering correctly. No negative marks for wrong answer. • Unanswered / wrongly answered questions pass to the next team. You get 5 seconds to answer it and five points for answering correctly.

24. Round 4 – Part I Alphabets A for ??? B for ???

25. Team D What does the Greek alphabet ‘’ stand for in  opioid receptors?  for deferens (as this receptor in vas deferens of mouse was not acted by morphine)  and  stand for morphine and ketazocine respectively as these drug activated the corresponding receptor 2. What does ‘D’ denote in actinomycin D? ‘D’ denotes the order of identification. This was the fourth actinomycin to be isolated from various species of actinomycetes.

26. Team A In early diastole, a cation channel permeable to Na+ and K+ is activated giving rise to an inward current called ‘If’. What does ‘f’ stand for here? ‘f’ for funny, because it is unusual for cation channels to be activated by hyperpolarisation 2. What does ‘F’ stand for in prostaglandin F? F for fosfat(as PGF partitioned into phosphate buffer while isolation. In Swedish ‘fosfat’ means phosphate) In PGE, ‘E’ stands for ether (as PGE partitioned into ether layer while isolation)

27. Team B What does ‘G’ stand for in penicillin G? The fermentation tanks used in the manufacture of penicillin were named as Tank A, Tank B, and so on. From tank G, benzyl penicillin was isolated, hence the name. 2. What does ‘G’ stand for in G protein? G for guanine nucleotide binding

28. Team C What does ‘P’ stand for in P glycoprotein? P for permeability. 2. What does ‘P’ stand for in cytochrome P450? P for pigment. (Cytochrome enzymes are hemoproteins. In its reduced form, it binds carbon monoxide to give a pigment that absorbs light maximally at 450 nm.)

29. Round 4 – Part II Numbers

30. Team C Chinese hamsters have a low chromosome number when compared to other laboratory animals and hence suited for cytological, genetic and radiation research. How many chromosome do they have? 22 2. According to Schedule Y, what is the time period within which the investigator should report all serious and unexpected adverse events to the ethics committee that accorded approval? Within seven working days

31. Team B At what age (in days), is a rat physiologically similar to a 6 month old infant? One day (24 hours) 2. What is the minimum number of members needed in an ethics committee (quorum) for reviewing a research protocol? Five

32. Team A How many patients should be observed to have a 95% chance of detecting one case of an adverse drug reaction with an incidence of 1 in 1000? 3000 2. How many items are there in the latest (2010) CONSORT checklist for reporting randomised controlled trials? 25

33. Team D For any competitive antagonist, how much is pA2 – pA10? 0.95 2. After how many years does a patent expire? 20 years

34. Round 5 Time Machine

35. Rules for Round 5 • We all will be travelling in a time machine in this round. First we travel into the past (Part 1 – Rewind) and then into the future (Part 2 – Fast forward). • The time line is mentioned at the top of each question. • Every team will get one question in each part. Each question in Part 1 has two subdivisions. • You have 30 seconds to answer each question. • Ten points for answering each subdivision correctly. No negative marks for wrong answer. • Unanswered / wrongly answered questions pass to the next team. You get 5 seconds to answer it and five points for answering each subdivisions correctly.

36. Round 5 - Part I Rewind

37. 1942 Team A a. Identify this building in Brooklyn which was announced as a historical monument in 2008. b. What are the huge structures (in close up view) near the building known as?

38. Answer • Pfizer’s first plant to commercially produce penicillin in large quantities • b. Fermentation tanks for producing penicillin

39. 1885 Team B a. An American surgeon while looking for a digestible bread substitute accidentally left a pot of boiled wheat to stand. This emerged as large, thin flakes. His patients liked it so much and he went on to develop corn flakes. Identify him. b. He practiced holistic medicine and advocated diet as a medicine. His principles and life history was taken as a film in 1994. Name this film.

40. Answer • Dr.John Harvey Kellogg • b. The Road to Wellville

41. 1863 Team C a. J. A. Bayer discovered malonylurea on December 4, 1863. The same day he visited a tavern patronised by artillery officers. December 4 is the feast day of the patron saint of artillery. He named this new substance after the saint. Name this saint. b. This substance is the parent compound of a group/class of drug. Name this group.

42. Answer • Saint Barbara • Bayer named the new compound as Barbituric acid • b. Barbiturates

43. 1550 BC Team D This is one of the oldest preserved medical document which contains a separate section on remedies. Identify it. Explain how it got its name.

44. Answer • Ebers Papyrus • This was purchased from a farmer (who found it near a mummy) by George Ebers, a German Egyptologist and novelist. Hence the name. • Ebers retired from his chair of Egyptology at Leipzig but the papyrus still remains in the University of Leipzig library.

45. Round 5 - Part II Fast Forward

46. 2012 Team D This illustration is about a new technique to produce human proteins from plants. Taliglucerase, the first drug made by this technique is expected to be approved by 2012. Name this technique.

47. Answer Pharming - using genetically engineered plants/ plant cells to produce proteins, vaccines and antibodies for therapeutics. Taliglucerase is a recombinant form of human glucocerebrocidase (for use in Gaucher’s disease) produced in genetically engineered carrot cells. Pharmacologists are going to become pharmers in the near future.

48. 2013 Team C Genetic circuits have been designed to produce drugs. One such application is the production of a plant derived drug by genetic circuits in yeast. A plant derived drug that revolutionised the treatment of a disease is now in short supply and costly. The genetically derived preparation of this drug is expected by 2013. Identify this drug.

49. Answer Artemisinin

50. 2019 Team B This is a video showing the future innovations in health care. Which organisation has the vision to achieve this by 2019?