Punnett Squares, Pedigrees and Karyotypes

1. Directions: Please answer the following questions. 21. How many total chromosomes are in the karyotype - count them _________ 22. What is the sex of this individual? __________________________ 23. Please name this karyotype. _______________________________ PunnettSquares, Pedigrees and Karyotypes 24. What diagnosis would you give this patient (what disease)?___________________ 25. How many total chromosomes are in the karyotype - count them _________ 26. What is the sex of this individual? __________________________ 27. Please name this karyotype. _______________________________ 28. What diagnosis would you give this patient (what disease)?___________________ 29. How many total chromosomes are in the karyotype - count them _________ 30. What is the sex of this individual? __________________________ 31. Please name this karyotype. _______________________________ 32. What diagnosis would you give this patient (what disease)?___________________

2. Punnett Squares, Pedigrees and Karyotypes 33. On your first day interning in the office of a human geneticist, a man with purple ears walks in. You questioned the man and wrote down the following family history. The man's mother and one of his sisters also had purple ears, but his father, his brother, and two other sisters had normal ears. The man and his normal-eared wife had seven children, including four boys and three girls. Two girls and two boys had purple ears. Draw the family pedigree and indicate what form of inheritance that the purple-ear trait most likely follows. Include the genotypes of all individuals.

3. Punnett Squares, Pedigrees and Karyotypes 34. Ray and Elaine were married in 1970. They both had normal vision. They had 2 daughters and then a son. Both daughters, Alicia and Candace, had normal vision and never had any children of their own. The son, Mike, was colorblind. The son married Beth who also had normal vision and they had 2 children of their own, first Greg then Victoria. Victoria was colorblind, but Greg was not. Colorblindness is a sex-linked recessive trait. Draw the family pedigree and include the genotypes of all individuals.

4. Punnett Squares, Pedigrees and Karyotypes Consider the accompanying pedigree of a rare autosomal recessive disease, PKU. 36. List genotypes of as many of the family members as possible. 37. If individuals A and B marry, what is the probability that their first child will have PKU? If their first child is normal, what is the probability that their second child will have PKU? If their first child has the disease, what is the probability that their second child will be unaffected? 38. The size of a Bio I student’s bladder is an inherited trait. It is controlled by single gene that has two alleles that are incompletely dominant. BB = Big Bladder, Bb = Medium Bladder, bb = Small Bladder It also happens to be true that the propensity for turning in your homework is a recessive X- linked trait. XI= will turn in work on time , Xi will turn in work late 1. Cross a Big bladder male who turns in work late with a medium bladder female who is heterozygous for turning in work. What are the expected genotypic/phenotypic ratios?

5. Punnett Squares, Pedigrees and Karyotypes In mice the ability to run normally is a dominant trait. Mice with this trait are called running mice ( R ). The recessive trait causes mice to run in circles. Mice with this trait are called waltzing mice ( r ). Hair color is also an inherited trait in mice. Black hair ( B ) is dominant over brown hair ( b ). 39. Cross a heterozygous running heterozygous black mouse with a homozygous running, homozygous black mouse. What is the expected phenotypic ratio? 40. Cross a homozygous running, homozygous black mouse with a heterozygous running, brown mouse. What are the expected phenotypic and genotypic ratios? 41. Cross a waltzing brown mouse with a waltzing brown mouse. What are the expected phenotypic and genotypic ratios?

6. Punnett Squares, Pedigrees and Karyotypes 42. Could a man with type B blood and a woman with type AB produce a child with type O blood?" 43. A wealthy elderly couple die together in an accident. Soon a man shows up to claim their fortune, saying that he is their only son who ran away from home as a boy. Other relatives dispute his claim. Hospital records show that the deceased couple were type AB and O respectively. The claimant to the fortune was type O. Could he be their son? Explain. 44. A man has type A blood and his wife has type B. A physician types the blood of their four children and is amazed to find one of each of the blood types among them. How could this happen?