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Histo On Your Nerves

Histo On Your Nerves. SSN Histology October 26th, 2004 Missy Walker, maw2106@columbia.edu So Young Kim, sk2298@columbia.edu. So what’s in a nerve?. Dendrite. Axon Terminal. Perikaryon. Nucleus of myelin-producing cells. Node of Ranvier. Axon. Myelin-Producing Cell. Axon Hillock.

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Histo On Your Nerves

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  1. Histo On Your Nerves SSN Histology October 26th, 2004 Missy Walker, maw2106@columbia.edu So Young Kim, sk2298@columbia.edu

  2. So what’s in a nerve? Dendrite Axon Terminal Perikaryon Nucleus of myelin-producing cells Node of Ranvier Axon Myelin-Producing Cell Axon Hillock

  3. Axon vs. Dendrite NO Synthetic Machinery! Axon Dendrite

  4. Nervous System Classifications

  5. Spinal Cord

  6. Spinal Cord: White Matter

  7. Myelin Production in CNS Oligodendrocytes

  8. Spinal Cord Gray Matter

  9. Spinal Cord Cajal’s Silver

  10. Meninges

  11. Astrocytes No collagen in the CNS!!!

  12. Brain

  13. Cerebellum

  14. Cerebellum

  15. Purkinje Cell

  16. Cerebral Cortex

  17. Cerebral Cortex

  18. Cerebellum vs. Cerebral Cx

  19. Cerebellum vs. Cerebral Cortex

  20. Pyramidal Cells vs. Spinal Cord Gray Matter

  21. Somatic Nervous System Innervates skeletal muscle For conscious movement Cell bodies in CNS Autonomic Nervous System Innervates smooth muscle and glands For organ function and regulation Cell bodies in CNS and PNS Sympathetic & Parasympathetic Peripheral Nervous System (PNS)Nervous tissue outside of the brain and spinal cord

  22. Sympathetic GANGLIA in thorax contain: neuronal cell bodies satellite cells (support cells of the neuron) Synapses occur Presynaptic fibers myelinated Postsynaptic fibers unmyelinated ANS - Ganglia

  23. Myenteric plexus in ENS Within Smooth Muscle of Gut NO Collagen (as in CNS) Glial cells (no Schwann cells) Nuclei are euchromatic Gut has “mind of its own” Enteric NS - Ganglia

  24. ENS Ganglion vs ANS Ganglion

  25. Organization by Connective Tissues Endoneuriumcollagen fibers associated with individual neurons -Schwann cells within Perineuriumlayer(s) of connective tissue cells, create fascicles Epineurium dense cnxtive tissue binding fascicles into a bundle Cross section of nerve

  26. Epineurium Perineurium Endoneurium Peripheral nerve

  27. Endoneurium Perineurium Epineurium Periph nerve - longitudinal section

  28. Longitudinal Section – Cajal stain

  29. Nodes of Ranvier Neurilemma (cytoplasm of Schwann cells) What’s the black? Peripheral Nerve – High Power (Cajal)

  30. What’s the purple? What’s the white? Peripheral Nerve – High Power (H&E)

  31. What’s the purple? Cross Section – Peripheral Nerve

  32. Why is this a Nerve, not a Ganglion? Peripheral Nerve

  33. Key Points for PNS • Ganglia • Contain cell bodies for motor ANS • Satellite cells are the supporting cell bodies (not glial, Schwann, or others of CNS) • Peripheral Nerves • Schwann cells make mylin sheath • Node of Ranvier / saltatory conduction / Na channels • Endoneurium around neurons, which form fascicles • Perineurium around fascicles, which form bundles • Epineurium around bundles

  34. Same or different?

  35. Same or different?

  36. What are these?

  37. B Questions 1 & 2. . . A

  38. Question 3. . . Figure A Figure B

  39. Question 4. . .

  40. Question 5. . .

  41. Question 6. . .

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