NIH Perspectives

1. NIH Perspectives Belinda Seto, Ph.D. Deputy Director National Institute of Biomedical Imaging and Bioengineering

2. NIH Funding to BWH • Total 569 awards, $313M • Research project grants $242M • Research centers $22.5M • T32 $7.1M (Advanced training in surgical oncology) • F32 $1.1M • K’s $40.3M

3. NIH Funding Opportunities http://grants.nih.gov/grants/oer.htm

4. CareerDevelopment (K) Awards Provide mentored support for early-career investigators who are transitioning to research independence. US citizens, non-citizen nationals, or permanent residents Up to 5 years of support At least 75% effort Caps on salary and research costs (NIBIB salary cap: $90k, research costs: $40k for K25 and K01 $105k, research costs: $40k for K08 and K23) Facilities and Administrative (F&A) costs: 8% Electronic Receipt Dates:February/June/October 12 (new) (1 month later for resubmission) Use the Career Wizard to find the right K award for you: http://grants1.nih.gov/training/kwizard/index.htm

5. Pathway to Independence Program(K99/R00 - Kangaroo Award) • Facilitate an earlier transition to a stable independent research position for new and talented investigators • US citizens, permanent residents and non-citizens on visas • No more than 5 years of postdoctoral experience • Applicants in dependent, postdoctoral positions • Individuals with independent positions at the Assistant Professor level or equivalent ineligible • Up to 5 years of support in 2 phases: • K99 Mentored/Postdoctoral Phase • R00 Independent Phase

6. Pathway to Independence Program(K99/R00 - Kangaroo Award) – cont. Phase I – K99 Mentored postdoctoral support • 1-2 years (NIBIB minimum:1 year) • At least 75% effort • Postdoc salary, limited research support • (NIBIB: $50K salary, $20K research costs) • Facilities and Administrative (F&A) costs at 8% Phase II– R00 Independent support • Contingent upon securing an independent faculty position and administrative review • Up to 3 yrs independent support • Up to $249,000/yr total cost, with full F&A costs • At least 75% research effort

7. Pathway to Independence Program(K99/R00 - Kangaroo Award) – cont. K99/R00 Program Announcement: http://grants.nih.gov/grants/guide/pa-files/PA-10-063.html Pathway to Independence Award Website  http://grants1.nih.gov/grants/new_investigators/index.htm#indaward Electronic Receipt Dates: February/June/October 12 (1 month later for resubmissions)

8. Paul Beeson Patient-Oriented Career Development Award in Aging • To promote research careers of clinically-trained individuals in pursuing research careers in aging • Health and independence • Diseases and disabilities of old age • Alzheimer disease and other neurodegenerative diseases • Clinical management • Systems of care • RFA-AG-14-013

9. Paul Beeson Awards (con’t) • Supported by NIA, NINDS, reviewed by special study section on aging • K23 funding mechanism • 3-5 years of mentored research, 75% research effort • $200K direct costs/year for 3 years, • $700K for 4 years and $800K for 5 years

10. K- Award Summary Mechanism Salary Research Costs Duration/ Effort K01 – Mentored Research Scientist Development Award $90,000 $40,000 3-5 years 75% effort K25 – Mentored Quantitative Research Career Development Award $90,000 $40,000 3-5 years 75% effort K08 - Mentored Clinical Scientist Development Award $105,000 $40,000 3-5 years 75% effort K23 - Mentored Patient-Oriented Research Career Development Award $105,000 $40,000 3-5 years 75% effort 1-2 years 3 years / 75% effort K99/R00 -Pathway to K99 Independence Award R00 $ 50,000 → $25,000 $249K total

11. NIH Director’s New Innovator Awardhttp://grants.nih.gov/grants/guide/rfa-files/RFA-RM-10-009.html • Goals: • Stimulate highly innovative research • Support promising new investigators • Differences from R01 • Exceptionally innovative ideas at an early career stage, • Preliminary data not required but allowed • No detailed, annual budget • Review emphasis on creativity, innovativeness and potential impact • $300,000/year for 5 years

14. NIBIB Research Education Program for Residents and Fellows (Institutional award, R25) • Target groups: residents or fellows interested in developing research experience in interdisciplinary areas such as quantitative biology, biologically-inspired engineering, and/or imaging science . • 12 month initial support, additional 12 months possible • 75% effort • $70,000 direct costs including $10,000 research supplies and $1000 travel

15. An Insider’s Advice

16. Key Points • The NIH is not one organization, but 27 individual Institutes and Centers, each with a culture and priorities. • Let science drive your applications; don’t decide on which ICs based on its appropriation • Seek advice from program directors about your ideas • Program directors are your advocate and can help with funding recommendations • NIH is considering support for people vs projects

17. I don’t need help if I have… • A great idea to solve a significant biomedical problem • An innovative solution • The tools to get the job done • right team • right resources • enough data to support • Outlined the path to get there with a compelling application • following the format • including all administrative requirements • Feasibility • Successfully posted the application through grants.gov

18. For everybody else… …Buckle Up: here we go!

19. NIH Grant Statistics • Fiscal Year 2012 • 51,836 total applications • 3,875 K applications • NIH success rate 19% • K awards success rate 32% • NIBIB success rates: RPG 12.7%;

20. Authorized Organizational Reps Research Administrator Principal Investigator Grants Management Review Staff Program Staff Communication is Key APPLICANT NIH

21. Need Help with Your Proposal… Who Ya’ Gonna’ Call? • Scientific and technical aspects of your application… • Find them on the solicitation • See also the IC’s programmatic descriptions (http://www.nih.gov/icd/index.html) • Questions during the review…. • Listed on the eRA Commons link to your submitted proposal • See also the review group rosters at the CSR web site • Help with the business aspects of a proposal… • Listed on the eRA Commons link to your submitted proposal • See also the IC’s programmatic descriptions (http://www.nih.gov/icd/index.html). Program Director Grants Specialist Scientific Review Officer

22. Application Award NIH Program Staff Pre-Application • Assess the “fit” • What’s New: Federal Opportunity Announcements (FOAs) • RFA • PA • PAR, PAS • Review Issues: Dos/Don’ts Post Review • Review Summary Statement • What the rating means • Strengths and weaknesses • Likelihood of funding • Next steps Review

23. Current Submission Rules • The NIH will accept only a single amendment to an original new or competing renewal application. • Failure to receive funding after two submissions (i.e., the original and the single amendment) will mean that the applicant should substantially re-design the project rather than simply change the application in response to previous reviews. • It is expected that this policy will lead to funding high quality applications earlier, with fewer resubmissions.

24. What’s New? • Big Data, http://BD2K.nih.gov • BRAIN, stay tuned form FOAs to be released by December 2013

26. Myriad Data Types Genomic Other ‘Omic Imaging Phenotypic Exposure Clinical

27. http://bd2k.nih.gov

28. BD2K: Four Programmatic Areas • FacilitatingBroad Use ofBiomedicalBig Data • II. Developing and Disseminating Analysis Methods and Software for Biomedical Big Data • III. Enhancing Training for Biomedical Big Data • IV. Establishing Centers of Excellence for Biomedical Big Data

29. BD2K: Four Programmatic Areas • IA. Facilitating Broad Use of Biomedical Big Big Data -- Data Catalog • RFI responses received – June 25 • 62 responses received • Data Catalog Workshop held Aug 21, 22 • Fran Berman, chair • Jenny Larkin (NHLBI), Ron Margolis (NIDDK), co-organizers

30. BD2K: Four Programmatic Areas • IB. Facilitating Broad Use of Biomedical Big Big Data – Data/Metadata Standards • Frameworks for Community-based Standards Efforts Workshop • September 25,26 • Susanna Santone & David Kennedy, co-chairs • Mike Huerta (NLM), Leslie Derr (OD) co-org

31. BD2K: Four Programmatic Areas • IC. Facilitating Broad Use of Biomedical Big Data -Enabling research use of clinical data • Workshop September 11, 12 • Robert Cardiff & Dan Masys, co-chairs • Leslie Derr (OD), Jerry Sheehan (NLM) co-org • Webcast w/ real-time, online discussion forum • To identify actionablesteps that NIH can take to accelerate the use of clinical data in research • Near and long-term needs for research, infrastructure, standards and policies • Organizers are collecting information about relevant initiatives

32. BD2K: Four Programmatic Areas • II. Developing and Disseminating Analysis Methods and Software for Biomedical Big Data • FOAs for BD2K-specific software needs in FY15 • RFI issued August 8, responses due Sept 6 • 4 topic areas: data visualization, compression/reduction, provenance, wrangling • Software Catalogue Workshop: • Feb 18-19, 2014 • Chairs: AsifDhar and Owen White

33. BD2K: Four Programmatic Areas • II. Developing and Disseminating Analysis Methods and Software for Biomedical Big Data • Cloud computing: • joint BD2K-Infrastructure Plus working group initiated • on-going discussion with NCI, joint survey results being written up • on-going discussion with commercial providers.

34. BD2K: Four Programmatic Areas • II. Developing and Disseminating Analysis Methods and Software for Biomedical Big Data • Dynamic Community Engagement: micro-blog and twitter developed for BD2K workshops

35. BD2K: Four Programmatic Areas • III. Enhancing Training for Biomedical • Big Data • RFI, >100 responses received • Workshop held July 29, 30 • Karen Bandeen-Roche, Zak Kohane, co-chairs • Michelle Dunn (NCI), Bettie Graham (NHGRI), organizers • Webcast, archived

36. BD2K: Four Programmatic Areas • III. Enhancing Training for Biomedical • Big Data – Workshop recommendations • Opportunity for extraction of knowledge from Big Data is often highest at the interface of at least two disciplines; training programs should be designed to work at interfaces • Training programs should be designed to provide skills to work effectively in Team Science • Dual mentoring should be encouraged • Flexibility needed to encourage innovation and to take best advantage of local expertise and talent • Trainees need access to large data sets

37. BD2K: Four Programmatic Areas • III. Enhancing Training for Biomedical • Big Data – Workshop recommendations • Training in quantitative science and experimental design will be increasingly important to clinical researchers and even clinicians • Principles of reproducible research must be stressed • There are training needs across the full spectrum of scientists, in terms of both experience and activities • The jobs that need to be done in effective Big Data science may not correspond to traditional academic jobs • A diverse workforce should be a major goal of data science training activities

38. BD2K: Four Programmatic Areas • IV. Establishing Centers of Excellence • for Biomedical Big Data • Investigator-initiated centers • FOA released July 22 • Applications due November 20 • Technical Information Webinar Sept 12 • NIH-Initiated centers • LINCS-BD2K Data Coordination and Integration Center (+ $2.5M from Common Fund) • Principles being developed

39. Nature | News & Views: Alzheimer's disease: From big data to mechanism VivekSwarup & Daniel H. Geschwind This work is also exemplary in demonstrating the extraordinary value of publicly available data resources. Published data on human gene expression, Alzheimer's disease GWAS and neuroimaging provide the pillars of Rhinn and collaborators' paper. Integrative analyses of these data by the authors, and previously by others, weaken the view that substantive biological experimentation only takes place at the wet bench, and highlight the value of innovative re-analyses of existing data.

40. Nature | News & Views: Alzheimer's disease: From big data to mechanism VivekSwarup & Daniel H. Geschwind This work is also exemplary in demonstrating the extraordinary value of publicly available data resources. Published data on human gene expression, Alzheimer's disease GWAS and neuroimaging provide the pillars of Rhinn and collaborators' paper. Integrative analyses of these data by the authors, and previously by others, weaken the view that substantive biological experimentation only takes place at the wet bench, and highlight the value of innovative re-analyses of existing data.

41. Nature | News & Views: Alzheimer's disease: From big data to mechanism VivekSwarup & Daniel H. Geschwind This work is also exemplary in demonstrating the extraordinary value of publicly available data resources. Published data on human gene expression, Alzheimer's disease GWAS and neuroimaging provide the pillars of Rhinn and collaborators' paper. Integrative analyses of these data by the authors, and previously by others, weaken the view that substantive biological experimentation only takes place at the wet bench, and highlight the value of innovative re-analyses of existing data.