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Pesticide Exposure and Neurodevelopment in the Fetus. Marcel Elizondo July 2009 STEER Student UTHSCSA-Harlingen. Pesticides. What is a pesticide?
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Pesticide Exposure and Neurodevelopment in the Fetus Marcel Elizondo July 2009 STEER Student UTHSCSA-Harlingen
Pesticides • What is a pesticide? • According to the EPA, a pesticide is “any substance or mixture of substances intended for preventing, destroying, repelling, or mitigating any pest” • What about pests? • Pests are “living organisms that occur where they are not wanted or that cause damage to crops or humans or other animals”4
Pesticides • Some examples of pests include: • Pests include mosquitoes, beetles, ants • How do pesticides kill pests? • Pesticides attack the nervous system of the pests which in turn leads to their untimely demise5
Elimination of Pesticide Use • Stockholm Convention on Persistent Organic Pollutants • This agreement was signed by 90 countries in 2001 to eliminate the use of 12 POPs including DDT • The World Health Organization made an exception in 2006 to back the use of DDT to control malaria in certain countries2
Pesticide Use • In the US, our agricultural areas use more than 75% of conventional pesticides • Exposure to pesticides has been linked to preterm birth and reduced fetal growth • A popular pesticide used to be dichlorodiphenyltrichloroethane (DDT), which was subsequently banned in the US in the 70’s • Currently, replacement pesticides for DDT are insecticides such as organophosphates.1
Effects of Some Pesticides • Organochlorines (i.e. DDT) • Excitation of central nervous system which leads to tremors, hyperexcitability and convulsions (both tonic and clonic) • Organophosphate (i.e. insecticides) • Act by inhibiting the acetylcholinesterase in synaptic clefts1
Organophosphate Detection • Exposure to organophosphates is usually measured by nonspecific metabolites in urine known as dialkyl phosphate (DAP) metabolites1
DO NOT offer your friends pesticides as a home remedy for cough.
Human Studies • Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) • Research is funded by NIH and EPA • Four objectives of CHAMACOS • Six hundred and one pregnant woman were recruited in 1999-2000. They were at least 18 years old and were less than 20 weeks in their gestation period2
CHAMACOS • Neonatal neurodevelopment was tested using the Brazelton Neonatal Behavioral Assessment Scales (BNBAS) • Maternal serum samples of DDT and DDE were higher than the National Health and Nutrition Examination Survey reference population • A minor negative association was observed between maternal DDE serum levels and abnormal infant reflexes2
CHAMACOS • Most other studies conducted had similar results to the CHAMACOS study • One exception was a study in North Carolina with a birth cohort of 912 infants • In utero exposure discovered that higher levels of DDE in the cord serum and breast milk led to hyporeflexia • This exception is noted because a similar (although smaller) cohort in Oswego, NY was conducted and the North Carolina findings could not be replicated2
Spanish Study • Cohort of 92 children • Exposed to high levels of DDE • Had lower social, mental and psychomotor development (assessed using Griffiths Scales of Infant Development and BSID-II)2
Mexican Study • DDE exposure in utero • Study found a decrease in psychomotor development using BSID-II at 3, 6 and 12 months2
Common theme • The common result from the CHAMACOS, Spanish, and Mexican studies suggests that DDE may have a negative effect on psychomotor development in infants less that 12 months of age • Only the North Carolina cohort had a positive association with decreased mental development at 6 months of age2
How Bad can Pesticide Exposure Be? • First, we need to determine what the “environment” in relation to pregnancy • One known example of a hazardous environmental toxin is tobacco smoke • The neonatal “environment” can include nutrition, adequacy of prenatal care, smoking, alcohol use, maternal age and socioeconomic conditions • Two or more of these factors might be related or synergistic3
Physical Environmental • A mother’s physical environmental is what most of us are familiar with • Air, water, food, soil and a number of consumer products • A mother’s placenta is thought of to protect a fetus against any toxins encountered, however some cases have shown the placenta to actually magnify hazardous maternal exposures3 Santa Ana Wildlife Reserve
Physical Environmental • For some persistent and bioaccumulative exposures (i.e. organochlorine pesticides), fetal exposure can occur as a result of maternal body burdens from years of preconceptional exposures • Fathers are just as accountable for exposures since their preconceptional exposures contribute to the risk through a mutagenic mechanism involving the sperm3
Neurodevelopmental Effects • Not specifically targeting pesticide exposure, environmental contaminants have been known to have adverse effects on brain and neurological development • Some developmental disabilities include ADHD, learning disabilities, autism, mental retardation and effects on the nervous system • Studies have shown that the window of susceptibility is with prenatal exposures • “Toxicological studies link both prenatal and postnatal exposure to organophosphate pesticides to neurodevelopmental effects”3
Limitations • This research focused on prenatal exposure and not on adolescent or adult effects
Future Research • Due to limited human population studies of pesticide exposure, more research is needed particularly with preconception exposures. This research should include both maternal and paternal exposures.
Recommendations • One recommendation for the detection of pre-exposure to the fetus • Include a questionnaire during prenatal care about possible environmental exposures for the expectant parents • This environmental assessment should be particularly conducted in agricultural communities where pesticide exposure is more prominent
You too can be a basketball star without excessive exposure to pesticides.
References • Rosas, L.G. and Eskenazi, B. (2008). Pesticides and Child Neurodevelopment. Current Opinion in Pediatrics, Vol. 20, 191-197. • Eskenazi, B., Rosas, L.G., Marks, A.R., Bradman, A., Harley, K., Holland, N., Johnson, C., Fenster, L., & Barr, D.B. (2008). Pesticide Toxicity and the Developing Brain. Basic & Clinical Pharmacology & Toxicology, Vol. 102, 228-336. • Stillerman, K.P., Mattison, D.R., Giudice, L.C., & Woodruff, T.J. (2008). Environmental Exposures and Adverse Pregnancy Outcomes: A Review of the Science. Reproductive Sciences, Vol. 15 (7), 631-650. • US Environmental Protection Agency. About pesticides. 2006. Available at: http://www.epa.gov/pesticides/about/index.htm. Accessed July 25, 2009. • American Pregnancy. Pesticides Exposure During Pregnancy. 2009. Available at: http://www.americanpregnancy.org/pregnancyhealth/pesticides.html. Accessed July 25, 2009.
This presentation was created in memory of Dr. Kirby “K.C.” Donnelly