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tnf- a (fold change)

Figure S1. D. A. IL-12 (pg/ml). il-12 (fold change). Cytokine (pg/ml). mRNA levels. B. E. IFN g (pg/ml). ifn- g (fold change). Donor 1. Donor 1. Donor 1. Donor 1. Donor 1. Donor 1. Cytokine (pg/ml). Donor 2. Donor 2. Donor 2. Donor 2. Donor 2. Donor 2. mRNA levels. C.

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tnf- a (fold change)

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  1. Figure S1 D A IL-12 (pg/ml) il-12 (fold change) Cytokine (pg/ml) mRNA levels B E IFNg(pg/ml) ifn-g (fold change) Donor 1 Donor 1 Donor 1 Donor 1 Donor 1 Donor 1 Cytokine (pg/ml) Donor 2 Donor 2 Donor 2 Donor 2 Donor 2 Donor 2 mRNA levels C F tnf-a (fold change) TNFa (pg/ml) Cytokine (pg/ml) mRNA levels

  2. Figure S1. Comparative pro-inflammatory transcriptional responses of human PBMCs (2 donors) for reference strains for il-12, ifn-γ and tnf-α (A, B, C) 4 h after stimulation with references and 3 P. freudenreichii strains (MOI of 10) and the corresponding TNFα, IL-12 and IFNγ cytokine responses (D, E, F) at 24 h. Methodology is similar as described for Fig. 1.

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