1 / 23

TNF a inhibitors

TNF a inhibitors . BY: MOHAMMED ALSAIDAN. Biologics . Biologic agents are proteins that can be extracted from animal tissue or produced by recombinant DNA technology and possess pharmacologic activity. TNF a . TNF a is a major cytokine produced by Th1 cells, APC and keratinocytes

leal
Download Presentation

TNF a inhibitors

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. TNF a inhibitors BY: MOHAMMED ALSAIDAN

  2. Biologics Biologic agents are proteins that can be extracted from animal tissue or produced by recombinant DNA technology and possess pharmacologic activity

  3. TNF a • TNF a is a major cytokine produced by Th1 cells, APC and keratinocytes • TNF a in the lesion and serum level correlate with severity of psoriasis • TNF potentiate Th1 response, up-regulate intracellular and vascular adhesion, cause keratinocytes proliferation and potentiate other cytokines

  4. TNF a adverse effects • Viral, bacterial and mycobacterial infections (less with etanercept) ( HCV ?!) • Neurologic disease • Heart disease • Drug induced lupus-like syndrome • Hepatic disease (infliximab) • Lymphoma • Melanoma and non-melanoma skin cancer • Haematologic disease

  5. Monitoring • PPD +/- CXR • CBC , U/E , LFT • Hepatitis panel • ANA

  6. Injections • Should not be frozen • Stable for 14 days • Allow for return to room temp before injection • Site : thigh, abdomen, upper arms • Rotate injection site

  7. Indications for Etanercept • FDA approved for psoriasis and psoriatic arthritis • Off label dermatologic uses: • Neutrophilicdermatoses: PG, behcet , aphthous stomatitis • Bullous dermatoses: PV, CP • Sarcoidosis • DM, relapsing polychondritis • GVHD, hidradenitissuppurativa, multicentricreticulohistiocytosis

  8. T cell activation inhibitors

  9. IL 12/23 blockage (Ustekinumab) • The p40 subunit of IL 12 is overexpressed in psoriasis • It is a human monoclonal antibody • Superior to etenercept • Given 45 mg S.C at weeks: 0,4, 16, 28

  10. THANK YOU

More Related