Sup Fig 1

A CFP YFP B CFP bleach YFP C Sup Fig 1

Sup Fig 2

A A549 A549 B R1 R1 R2 R2 R3 R3 R1 R1 R2 R2 R3 R3 kDa kDa 57 58 PDIA3 PDIA1 46 46 βActin βActin + + + + + + - - - - - - siCrtl siPDIA1 siCrtl siPDIA3 - - - - - - + + + + + + R.D. R.D. 1 1 1 1 1 1 0.80 0.20 0.43 0.48 0.48 0.70 D C A549 A549 R1 R1 R2 R2 R3 R3 R1 R1 R2 R2 R3 R3 kDa kDa PDIA4 PDIA4 72 72 PDIA6 PDIA6 48 48 βActin βActin 46 46 + + + + + + - - - - - - siCrtl siPDIA6 siCrtl siPDIA4 - - - - - - + + + + + + R.D. R.D. 1 1 1 1 1 1 0.45 0.10 0.11 0.05 0.16 0.20 Sup Fig 3

A R1 C siCrtl siPDIA4 siPDIA6 100 95 90 85 80 75 70 0 5.5 6 3 NT Cell survival (%) Cell count 7 31 22 / 25µM CDDP 25µM CDDP TMRM (m) B C D R1 siCrtl siPDIA4 siPDIA6 3 5 6 NT Cell count 36 8 24 25µM CDDP Cell count h h SubG1 Caspase 3-7 activity (RFU) Supp Fig 4 25µM CDDP

A2780R 8.5 21 8.3 58 25 13 13 45 63 28 A C siCrtl siPDIA4 siPDIA6 A2780R kDa 72 PDIA4 kDa βActin 48 46 PDIA6 NT βActin siCrtl siPDIA4 46 + - - + Cell count siCrtl siPDIA6 + - - + 53 25µM CDDP TMRM (m) B D A2780R A2780R siCrtl siPDIA4 siPDIA6 siCrtl siPDIA4 siPDIA6 23 1.8 5.15 2.9 6.2 1.6 8.27 NT NT 91.2 90 89 Cell count Annexin-PE(+) 9.0 7.8 8.9 33.90 9.1 67.3 25µM CDDP 25µM CDDP 82.3 56.4 20.8 7AAD(+) SubG1 Sup Fig 5

120 100 80 60 40 20 R1 R2 R3 0 Cell viability(%) Crtl. NT Crtl PDIA4 PDIA6 Crtl. PDIA4 PDIA6 Oxaliplatinum (µM) - - 25 50 25 50 25 50 - - - - - - Carboplatinum (µM) - - - - - - - - 25 50 25 50 25 50 Sup Fig 6

Sup Fig 1

Sup Fig 1

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