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Sup. Fig. 1

Sup. Fig. 1. 100. Cell number (x 10 5 cells). 10. 1. 0. 20. 40. 60. 80. hours. Sup. Fig. 2. HER2 amplification (+). HER2 amplification (-). Sup. Fig. 3. CpG site no. CpG site no. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 1. 2. 3. 4. 5.

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Sup. Fig. 1

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  1. Sup. Fig. 1 100 Cell number (x 105 cells) 10 1 0 20 40 60 80 hours

  2. Sup. Fig. 2 HER2 amplification (+) HER2 amplification (-)

  3. Sup. Fig. 3 CpG site no. CpG site no. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Clone no. Clone no. 1 1 2 2 3 3 3OST2 [Case# 31] FLNc [Case# 10] 4 4 5 5 6 6 7 7 8 8 9 9 10 10 CpG site no. CpG site no. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 6 1 2 3 4 5 7 8 9 10 11 12 13 Clone no. Clone no. 1 1 2 2 3 3 GREM1 [Case# 15] THBD [Case# 4] 4 4 5 5 6 6 7 7 8 8 9 9 10 10 11 11 12 12 13 CpG site no. CpG site no. CpG site no. 1 2 3 4 5 6 1 2 3 4 5 6 7 8 9 10 1 2 3 4 5 6 7 8 9 Clone no. Clone no. 1 1 Clone no. 1 2 2 2 3 3 XT3 [Case# 31] LOC346978 [Case# 9] 3 PCDH10 [Case# 22] 4 4 4 5 5 5 6 6 6 7 7 7 8 8 8 9 9 10 10 11 11 12 12 13

  4. Sup. Fig. 4 LOC346978 3OST2 GREM1 80 30 60 60 Methylation level (%) 40 20 40 10 20 20 0 0 0 Ca. Non-ca. Ca. Non-ca. Ca. Non-ca. PCDH10 FLNc XT3 80 40 80 60 30 60 Methylation level (%) 40 20 40 20 10 20 0 0 0 Ca. Non-ca. Ca. Non-ca. Ca. Non-ca. THBD CLDN3 CDKN2A 80 20 40 60 Methylation level (%) 40 20 10 20 0 0 0 Ca. Non-ca. Ca. Non-ca. Ca. Non-ca.

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