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Synthetic Biology at Davidson College

Synthetic Biology at Davidson College. Building Bacterial Computers. Advantages of Biological Computers. go anywhere - arctic, thermal vents, inside organisms. no electricity. self-replicating. no immune rejection. Two Recent Research Projects. Flipping DNA with Hin/ hixC.

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Synthetic Biology at Davidson College

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  1. Synthetic Biology at Davidson College Building Bacterial Computers

  2. Advantages of Biological Computers go anywhere - arctic, thermal vents, inside organisms no electricity self-replicating no immune rejection

  3. Two Recent Research Projects

  4. Flipping DNA with Hin/hixC

  5. Flipping DNA with Hin/hixC

  6. Flipping DNA with Hin/hixC

  7. Hamiltonian Path Problem 5 3 1 4 2

  8. Hamiltonian Path Solution 5 3 1 4 2

  9. Engineering Biological HPP

  10. Engineering Biological HPP

  11. Engineering Biological HPP

  12. Engineering Biological HPP

  13. Engineering Biological HPP Hin-mediated recombination

  14. Engineering Biological HPP

  15. Predicting Outcomes of Bacterial Computing

  16. Does Starting Place Matter?

  17. Does Starting Place Matter? Equilibrium

  18. How Many Plasmids Do We Need?

  19. Split Genes to Encode Problem

  20. Split Genes to Encode Problem gcat.davidson.edu/GcatWiki/index.php/Davidson_Missouri_W/Davidson_Protocols

  21. Split Reporter Genes Red Fluorescent Protein Green Fluorescent Protein

  22. Split Reporter Genes GFP Split by hixC RFP Split by hixC

  23. Paper Published 7/09 Paper of the year, 2009 15 undergraduate coauthors

  24. Can we solve the SATisfiability problem?

  25. Define the SATisfiability Problem

  26. Define the SATisfiability Problem

  27. Define the SATisfiability Problem

  28. Converting Math to Biology

  29. Central Dogma

  30. Frameshift Mutation

  31. Frameshift Suppression

  32. Suppressor tRNA

  33. Coding 2-SAT Clause

  34. Coding 2-SAT Clause

  35. Coding 2-SAT Clause

  36. Outcomes of v 1.0

  37. Outcomes of v 1.0

  38. Redesign System v2.0 positive feedback loop

  39. Outcomes of v 2.0 frame shift “leak” +tRNA CGGUC +tRNA CCACU - control + control

  40. Outcomes of v 2.0 frame shift “leak” +tRNA CGGUC +tRNA CCACU + control

  41. Why build bacterial computers?

  42. Evolution of Computers 1943

  43. Evolution of Computers iPhone in 2011

  44. Evolution of Bacterial Computers E. coli in 2011 ? Living Hardware in 2021

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