Organic Chemistry I Reactions of Alkenes and Alkynes Introduction to Organic Synthesis

1. Organic Chemistry IReactions of Alkenes and AlkynesIntroduction to Organic Synthesis Dr. Ralph C. Gatrone Department of Chemistry and Physics Virginia State University

2. Chapter Objectives • Introduce Organic Synthesis • Summarize reactions covered • Emphasize the need to know the reactions • Emphasize the need to know the reactions • I cannot emphasize the need to know the reactions enough. • You must realize that you need to know the reactions.

3. Learning Organic Reactions • Flash Cards • Consistent study • Effort required

4. Summary

5. Learn those reactions!

6. In other words … • Learn • The • Reactions! • Study • Your • Notecards!

7. Synthesis as • A tool for Learning Organic Chemistry • In order to propose a synthesis you must be familiar with reactions • What they begin with • What they lead to • How they are accomplished • What the limitations are • A synthesis combines a series of proposed steps to go from a defined set of reactants to a specified product • Remember your Note Cards for our Reactions

8. Strategies for Synthesis • Consider the target molecule • Consider the allowed starting materials • Consider reactions that efficiently give desired outcome

9. Retrosynthetic Analysis • Primary strategy • Consider target molecule • Consider what reaction will provide that molecule

10. Example • Prepare decane from 1-pentyne • You may use any inorganic reagents. • Starting material is 1-pentyne • You cannot use anything else.

11. Retrosynthetic analysis

12. Retrosynthetic Analysis Hydrogenation reduces triple bond to alkane

13. Retrosynthetic Analysis

14. Retrosynthetic Analysis

15. Retrosynthetic Analysis

16. Retrosynthetic Analysis

17. Retrosynthetic Analysis

18. The Synthesis

19. Synthetic Strategy • You must know the reactions.