organic chemistry reactions

1. Reaction Types To satisfy all the request from our customer, BOC Sciences adapts the latest or most effective method to synthesize target by chemical manipulation. With various types of reaction applied, we would provide customers with all the compounds they required in any scales and at lowest cost. Available Reaction Types (include but not limited to the following): Protection/Derivatization Derivatization is desirable for its reliable reaction and proceeds to completion, the stable products and degradation products. Especially in the synthesis of structurally complex compounds, designing the synthetic strategies such as selection of protecting groups and the efficient deprotection process are key steps to achieve. It is expected that a wide variety of protecting agents are available. Coupling Reaction Coupling reaction is one of the reaction where two fragments are coupled with the aid of catalyst. It is widely used in pharmaceutical industry. The first step is single electron transfer of the carbonyl bond, which generates radical ion intermediates that couple via carbon- carbon bond formation. C-H Activation C-H activation has an important, modern tool of organic synthesis for the omnipresence of C-H bonds in organic compound. And recently,

2. C-H activation becomes an effective and desirable method for its efficient catalyst developing the synthesis of fine chemicals, drugs. Figure 2. Cobalt-catalyzed C-H activation Reduction Classical reductions include alkene reduction to alkanes and classical oxidations include oxidation of alcohols to aldehydes. Many reactions classified as reductions also appear in other classes. But it is applied widely in the synthesis. Oxidation In oxidations electrons are removed and the electron density of a molecule is reduced. Oxidation is an effective way when the target compound contains less hydrogen atoms or is requested to be asymmetric. Hydrogenation Hydrogenation is a useful means for converting unsaturated compounds into saturated derivatives. Substrates include not only alkenes and alkynes, but also aldehydes, imines, and nitriles. Olefination The utility of this connective olefination reaction arises from its versatility, its wide functional group tolerance, and the mild reaction conditions under which the reaction proceeds. Up to now, various olefination comes to know for instance Julia olefination, Takai

3. olefination, Wittig olefination and so on. We believe the olefination used in your compound would be at lowest cost and highest efficient. Figure 3. Peterson Acidic Mechanism. Halogenation Halogenation is a chemical reaction that is employed to the addition of one or more halogens to a compound. The pathway of halogenation depends on the structural features and functional groups of the organic substrate, as well as on the specific halogen. Several method for Halogenation exist including free radical halogenation, ketone halogenation, electrophilic halogenation, and halogen addition reaction. Lithiation They are important reagents containing carbon-lithium bonds in organic synthesis. Organolithium species can generally be used as nucleophiles in asymmetric carbon-carbon and carbon-heteroatom bond formations via alkylation, aldol condensation, and opening of epoxides. Amination Amination is the process by which an amine group is introduced into an organic molecule. Amination can occur in a number of ways including reaction with ammonia or another amine such as an alkylation, reductive amination and the Mannich reaction. Cyanation

4. In Cyanation reaction, these is the attachment or substitution of a cyanide group. More importantly a direct cyanation of benzylic alcohols allows the synthesis of the corresponding nitriles in short reaction time with good yields. Phosphorylation As a significant modifications, Phosphorylation is especially important for protein function. Phosphorylation plays critical roles in the regulation of many cellular processes. Nitrosation The chemistry of nitric oxide, particularly in the field of S-nitration and the chemistry of S-nitro so compounds have developed most because nitrogen element plays unique role in human development. Chemistry of nitration reactions, dealing with both the synthetic and mechanistic aspects of these reactions, is researched and utilized. Diazotization Diazonium compounds are standard reagents used in synthesis of organic compounds, especially aryl derivatives. Diazonium salts are light sensitive and break down under near UV or violet light. This property has led to their use in document reproduction. Azidation Toward Azidation Reaction, it’s easy to convert secondary, tertiary, and benzylic C-H bonds to the corresponding azides. Azidation is highly energetic functional group, which introduction of N3 group into an organic compound increases its energy content by approx. BOC Sciences provides different Reaction to make sure the entire process is reliable, and can be repeated and applied in different conditions. All the compounds our customers need are guaranteed on

5. high quality standards and punctual delivery. Typical delivery specifications include: HPLC chromatogram Mass spec analysis Synthesis report Certificate of Analyses References 1. Tzouras, N. V., Stamatopoulos, I. K., Papastavrou, A. T., Liori, A. A. and Vougioukalakis, G. C. (2017) ‘Sustainable metal catalysis in CH activation’,Coordination Chemistry Reviews, 343: 25-138. 2. Werkmeister, S., Junge, K. and Beller, M. (2014) ‘Catalytic hydrogenation of carboxylic acid esters, amides, and nitriles with homogeneous catalysts’,Organic Process Research & Development, 18(2): 289-302. https://www.solutions.bocsci.com/reaction-types.htm