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Lipid Transport

Lipid Transport. Lipoproteins Chylomicrons VLDL = very-low-density lipoproteins LDL = low-density lipoproteins HDL = high-density lipoproteins. Copyright 2005 Wadsworth Group, a division of Thomson Learning. Animation. Lipid Transport. Lipid Transport. Lipoproteins and health

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Lipid Transport

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  1. Lipid Transport • Lipoproteins • Chylomicrons • VLDL = very-low-density lipoproteins • LDL = low-density lipoproteins • HDL = high-density lipoproteins Copyright 2005 Wadsworth Group, a division of Thomson Learning

  2. Animation Lipid Transport

  3. Lipid Transport • Lipoproteins and health • LDL vs. HDL Copyright 2005 Wadsworth Group, a division of Thomson Learning

  4. Roles of Triglycerides • Fat stores • Energy • Protection • Cushioning (e.g. fat pads on foot) • Insulation • Fat is a poor conductor of heat Copyright 2005 Wadsworth Group, a division of Thomson Learning

  5. Essential Fatty Acids • Remember that an essential nutrient is a nutrient which the body cannot make or make in sufficient quantities • Our cells cannot make omega-3 or omega-6 from scratch or convert one to another. • They can only elongate 16 carbon omega-3 or omega-6 and make longer chain fatty acids • Linoleic acid and the omega-6 family • Arachidonic acid Copyright 2005 Wadsworth Group, a division of Thomson Learning

  6. Essential Fatty Acids Copyright 2005 Wadsworth Group, a division of Thomson Learning

  7. Essential Fatty Acids • Linolenic acid and the omega-3 family • EPA =eicosapentaenoic acid (20 carbons) • DHA = docosahexaenoic acid (22 carbons) • Important for normal growth and development esp. eyes and brain • Maybe important for prevention and treatment of heart disease Copyright 2005 Wadsworth Group, a division of Thomson Learning

  8. Essential Fatty Acids • Eicosanoids • prostaglandins, thromboxanes, prostacyclin and the leukotrienes. • Both Arachidonic acid and EPA are used to make different types of eicosanoids • EPA derived vs. arachidonic acid derived • EPA derived ones are more protective • EPA derived eicosanoids help to protect against heart disease Arachidonic acid EPA Copyright 2005 Wadsworth Group, a division of Thomson Learning

  9. Essential Fatty Acids • Fatty acid deficiencies • Not very common • Usually only in infants and children who are fed fat free milk or low-fat diets or long term lack of polyunsaturated fatty acids in their diet • A deficiency of omega-3 fatty acids may be associated with depression

  10. Essential Fatty Acids Copyright 2005 Wadsworth Group, a division of Thomson Learning

  11. Storage as fat Adipose tissue LPL = lipoprotein lipase Lipid Metabolism Copyright 2005 Wadsworth Group, a division of Thomson Learning

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