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Plasma Lipid Transport Role of HDL

Philip Barter, MBBS, FRACP, PhD Professor and Director The Heart Research Institute, Sydney, Australia. Plasma Lipid Transport Role of HDL. Plasma Lipid Transport. Liver. Adipose tissue. CE. FC. TG. FFA. CE: cholesteryl ester FC: free cholesterol FFA: free fatty acids

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Plasma Lipid Transport Role of HDL

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  1. Philip Barter, MBBS, FRACP, PhD Professor and Director The Heart Research Institute, Sydney, Australia Plasma Lipid TransportRole of HDL

  2. Plasma Lipid Transport Liver Adipose tissue CE FC TG FFA CE: cholesteryl ester FC: free cholesterol FFA: free fatty acids TG: triglycerides

  3. Plasma Lipid Transport Liver VLDL Adipose tissue TG CE FC TG CE FFA CE: cholesteryl ester FC: free cholesterol FFA: free fatty acids TG: triglycerides

  4. Plasma Lipid Transport Liver VLDL Adipose and other tissues Adipose tissue FFA LPL TG CE FC TG CE FFA CE: cholesteryl ester FC: free cholesterol FFA: free fatty acids LPL: lipoprotein lipase TG: triglycerides

  5. Plasma Lipid Transport Adipose and other tissues Adipose tissue Liver LDL VLDL FFA LPL TG CE FC TG CE FFA TG TG CE CE: cholesteryl ester FC: free cholesterol FFA: free fatty acids LPL: lipoprotein lipase TG: triglycerides

  6. Plasma Lipid Transport Adipose and other tissues Adipose tissue Liver LDL Liver Cell in peripheral tissue VLDL FFA LPL TG CE FC TG CE FFA TG LDL receptor TG CE LDL receptor CE: cholesteryl ester FC: free cholesterol FFA: free fatty acids LPL: lipoprotein lipase TG: triglycerides CE

  7. Plasma Lipid Transport Adipose and other tissues Adipose tissue VLDL Liver LDL Liver Cell in peripheral tissue FFA LPL TG CE FC TG CE FFA TG LDL receptor TG CE LDL receptor CE: cholesteryl ester FC: free cholesterol FFA: free fatty acids LPL: lipoprotein lipase TG: triglycerides CE New synthesis FC

  8. Plasma Lipid Transport Cell in peripheral tissue Adipose and other tissues Adipose tissue VLDL Liver LDL Liver HDL FFA LPL TG CE FC TG CE FFA TG LDL receptor TG CE LDL receptor CE: cholesteryl ester FC: free cholesterol FFA: free fatty acids LCAT: lecithin cholesterol acytransferase LPL: lipoprotein lipase TG: triglycerides CE TG New synthesis TG LCAT CE FC

  9. Plasma Lipid Transport Adipose tissue Cell in peripheral tissue Liver LDL Liver Adipose and other tissues VLDL HDL FFA LPL TG CE FC TG CE CE FFA TG LDL receptor TG CE LDL receptor CE: cholesteryl ester FC: free cholesterol FFA: free fatty acids LCAT: lecithin cholesterol acytransferase LPL: lipoprotein lipase TG: triglycerides CE TG New synthesis TG LCAT CE FC

  10. Plasma Lipid Transport Adipose tissue Cell in peripheral tissue Liver LDL Liver Adipose and other tissues VLDL HDL FFA LPL TG CE FC TG CE CE FFA TG LDL receptor TG CE LDL receptor CE: cholesteryl ester FC: free cholesterol FFA: free fatty acids LCAT: lecithin cholesterol acytransferase LPL: lipoprotein lipase TG: triglycerides CE TG New synthesis TG LCAT CE FC

  11. Plasma Lipid Transport Adipose tissue Cell in peripheral tissue Liver LDL Liver VLDL HDL Adipose and other tissues FFA LPL TG CE FC TG CE CE FFA FC TG LDL receptor TG CE Bile LDL receptor CE: cholesteryl ester FC: free cholesterol FFA: free fatty acids LCAT: lecithin cholesterol acytransferase LPL: lipoprotein lipase TG: triglycerides CE TG New synthesis TG LCAT CE FC

  12. Plasma Lipid Transport Liver Adipose tissue Cell in peripheral tissue Liver LDL Adipose and other tissues VLDL HDL FFA LPL TG CE FC TG CE CE FFA FC TG LDL receptor TG CE Bile LDL receptor CE: cholesteryl ester CETP: cholesteryl ester transfer protein FC: free cholesterol FFA: free fatty acids LCAT: lecithin cholesterol acytransferase LPL: lipoprotein lipase TG: triglycerides CETP CE TG New synthesis TG LCAT CE FC

  13. Dyslipidemia in Diabetes and the Metabolic Syndrome HDL Adipose and other tissues VLDL Cell in peripheral tissue Liver LDL Liver Adipose tissue FFA LPL TG CE FC TG CE CE FFA FC TG LDL receptor TG CE Bile LDL receptor CE: cholesteryl ester CETP: cholesteryl ester transfer protein FC: free cholesterol FFA: free fatty acids LCAT: lecithin cholesterol acytransferase LPL: lipoprotein lipase TG: triglycerides CETP CE TG New synthesis TG LCAT CE FC

  14. Dyslipidemia in Diabetes and the Metabolic Syndrome HDL Adipose and other tissues VLDL Cell in peripheral tissue Liver LDL Liver Adipose tissue FFA LPL TG CE FC TG CE CE FFA FC TG LDL receptor TG CE Bile LDL receptor CE: cholesteryl ester CETP: cholesteryl ester transfer protein FC: free cholesterol FFA: free fatty acids LCAT: lecithin cholesterol acytransferase LPL: lipoprotein lipase TG: triglycerides CETP CE TG New synthesis TG LCAT CE FC

  15. Dyslipidemia in Diabetes and the Metabolic Syndrome HDL Adipose and other tissues VLDL Cell in peripheral tissue Liver LDL Liver Adipose tissue FFA LPL TG CE FC TG CE CE FFA FC TG LDL receptor TG CE Bile LDL receptor CE: cholesteryl ester CETP: cholesteryl ester transfer protein FC: free cholesterol FFA: free fatty acids LCAT: lecithin cholesterol acytransferase LPL: lipoprotein lipase TG: triglycerides CETP CE TG New synthesis TG LCAT CE FC

  16. Dyslipidemia in Diabetes and the Metabolic Syndrome VLDL HDL Adipose and other tissues Cell in peripheral tissue Liver LDL Liver Adipose tissue FFA LPL TG CE FC TG CE CE FFA FC TG LDL receptor TG CE Bile LDL receptor CE: cholesteryl ester CETP: cholesteryl ester transfer protein FC: free cholesterol FFA: free fatty acids LCAT: lecithin cholesterol acytransferase LPL: lipoprotein lipase TG: triglycerides CETP CE TG New synthesis TG LCAT CE FC

  17. Dyslipidemia in Diabetes and the Metabolic Syndrome VLDL HDL Adipose and other tissues Cell in peripheral tissue Liver LDL Liver Adipose tissue FFA LPL TG CE FC TG CE CE FFA FC TG LDL receptor TG CE Bile LDL receptor CE: cholesteryl ester CETP: cholesteryl ester transfer protein FC: free cholesterol FFA: free fatty acids LCAT: lecithin cholesterol acytransferase LPL: lipoprotein lipase TG: triglycerides CETP CE TG New synthesis TG LCAT CE FC

  18. Dyslipidemia in Diabetes and the Metabolic Syndrome HDL VLDL Adipose and other tissues Cell in peripheral tissue Liver LDL Liver Adipose tissue FFA LPL TG CE FC TG CE CE FFA FC TG LDL receptor TG CE Bile LDL receptor CE: cholesteryl ester CETP: cholesteryl ester transfer protein FC: free cholesterol FFA: free fatty acids LCAT: lecithin cholesterol acytransferase LPL: lipoprotein lipase TG: triglycerides CETP CE TG New synthesis TG LCAT CE FC

  19. www.cardiometabolic-risk.org

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