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(1) DNA damaging-agents: Rx, IR, ROS, etc. (2) cell g row/surv. (3) cell grow/surv. mitochondrial biogenesis (4). mitoch. biogenesis cell grow/surv. (5). (7). ROS . (8). (6) 2nd event cell grow/surv. Damage to nDNA Genetic instability.
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(1) DNA damaging-agents: Rx, IR, ROS, etc (2) cell grow/surv. (3) cell grow/surv. mitochondrial biogenesis (4) mitoch. biogenesis cell grow/surv. (5) (7) ROS (8) (6) 2nd event cell grow/surv. Damage to nDNA Genetic instability