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Wish That I Were Ever Young. Physically, Biologically, socially or Mentally. TWO MAJOR PROBLEMS OF THE LIVING WORLD. AGEING AND CANCER. We DON’T Like this. Or This. Would U like to chat. Why We grow old. Biological
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Wish That I Were Ever Young Physically, Biologically, socially or Mentally
TWO MAJOR PROBLEMS OF THE LIVING WORLD AGEING AND CANCER
Why We grow old • Biological • Economic • Social • Stress • Diet
And above all • GENETIC EXPRESSION
Know your diet • C +P+F • Vitamins • Anti-oxidants • Calories • Stimulants • Sedatives • CRAN
Ageing in humans refers to a multidimensional process of physical, psychological, and social change • Some dimensions of ageing grow and expand over time, while others decline.
What is "active ageing"? • Active ageing is the process of optimizing opportunities for health, participation and security in order to enhance quality of life as people age. It applies to both individuals and population groups.
“active” refers to continuing participation in social, economic, cultural, spiritual and civic affairs, not just the ability to be physically active or to participate in the labour force. Older people who retire from work, ill or live with disabilities can remain active contributors to their families, peers, communities and nations. Active ageing aims to extend healthy life expectancy and quality of life for all people as they age.
. • Population ageing is the increase in the number and proportion of older people in society. Population ageing has three possible causes: migration, longer life expectancy (decreased death rate), and decreased birth rate. Ageing has a significant impact on society
After a period of near perfect renewal (in humans, between 20 and 35 years of age), organismal senescence is characterized by the declining ability to respond to stress, increasing homeostatic imbalance and increased risk of disease
Process of Ageing( Gerontology) • What is life? • What is death? • Types of death ?
CHEMICAL GARBAGE • PROTEIN CROSS-LINKING & AGGREGATION • ADVANCED GLYCATION END-PRODUCTS (AGEs) • ATHEROSCLEROTIC AND AMYLOID PLAQUES
INFLAMMATORY CYTOKINES • LIPOFUSCIN • CORTISOL • METALS • DDT, PCBs, etc
Calcium & Magnesium magic • weakness, leg cramps, anxiety and confusion • Heart palpitations, "flutters" • hyper excitability, nervousness, mental confusion and difficulty coping with simple day-to-day problems
Apopotosis: Dance of Death • Cell death • Programmed cell signals • Mitochondria • Cytochrome c
Cell cycle control • Factors CI CII CIII • MPF
TELOMERE • CHROMOSOME • TELOMERE • DNA OF TELOMERE • ENZYME: TELOMERASE
TELOMERASE • A RIBO-NUCLEOPROTEIN • RNA CATALYST • CENTRAL DOGMA
hTERT • human Telomerase Reverse Transcriptase
Anti Ageing Agents • Antioxidant • Vit C, Vit E,vit D • Eat less • Stress Management
TELOMERASE • END DNA REPLICATION • TELOMERE SHORT SEGMENTS • CELL CYCLES SLOWS • CELL STOPS/ DIES • NO RELACEMENT • Telomerase declines with age
Three Americans received the Nobel Prize in Medicine this year for their research in figuring out how telomeres work
p 63 • P 53
How to control Cancer • Telomerase magic • Telomerase inhibitors