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MOVEMENT OF MELANOSOMES

MOVEMENT OF MELANOSOMES. FORMATION OF MELANOSOMES. MELANOSOMES (GREEN) MICROTUBULES (RED) F-ACTIN (BLUE). HUMAN SKIN. MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS. MELANOBLASTS DIVIDE TO FORM MELANOCYTES.

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MOVEMENT OF MELANOSOMES

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  1. MOVEMENT OF MELANOSOMES

  2. FORMATION OF MELANOSOMES

  3. MELANOSOMES (GREEN) MICROTUBULES (RED) F-ACTIN (BLUE)

  4. HUMAN SKIN

  5. MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS MELANOBLASTS DIVIDE TO FORM MELANOCYTES

  6. AN AUTO - IMMUNE DISEASE IN WHICH SOME MELANOCYTES ARE DESTROYED BY THE IMMUNE SYSTEM

  7. MELANSOMES ARE TAKEN UP BY PHAGOCYTOSIS INTO THE LOWER KERATINOCYTES

  8. INACTIVE TYROSINASE DUE TO MUTATION

  9. MUTATION CAUSING SOME IMPROPER FOLDING THAT DOES NOT AFFECT TYROSINASE ACTIVITY. BUT GOLGI QUALITY CONTROL SENDS IT BACK TO THE RER.

  10. CORRECT SUGARS ARE NOT ADDED TO OLIGOSACCHARIDES OF TYROSINASE. SO MISDIRECTED AT TRANS-GOLGI SYSTEM MAY BE PUT INTO SECRETORY VESICLES BY MISTAKE.

  11. LACK OF TYROSINE TRANSPORT SYTEM IN MELANOSOME MEMBRANE.

  12. LACK OF FUNCTIONAL TYROSINASE

  13. LACK OF TRANSFER TO KERATINOCYTES

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