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Zebra Fish

Zebra Fish. There are many zebrafish mutants with defective blood defects in heart development It is likely that blood function and heart development in zebrafish are similar to blood function and heart development in people.

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Zebra Fish

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  1. Zebra Fish • There are many zebrafish mutants • with defective blood • defects in heart development • It is likely that blood function and heart development in zebrafish are similar to blood function and heart development in people. • Some of these mutations might mimic human syndromes, and understanding them will provide us with valuable insight as to the underlying problem. • Such an understanding could lead to new treatments. In addition, many of the proteins involved in early development are critical in later life. Defects in these proteins, or in the regulation of their expression, can lead to tumors later in life.

  2. Aquaria Hazards • Mycobacterium - Organisms in the genus Mycobacterium are nonmotile, acid-fast rods. Two species, M. fortuitum and M. marinum, are recognized as pathogens of tropical fish. Humans are typically infected by contamination of lacerated or abraded skin with aquarium water or fish contact.

  3. Zoonotic Aquaria Hazards • Aeromonas spp.- gastrointestinal disease and wound infections • Gram-negative Organisms: Plesiomonas shigelloides, Pseudomonas fluorescens, Escherichia coli, Salmonella spp., Klebsiella spp., Edwardsiella tarda • Gram-positive Organisms: Streptococcus, Staphylcocccus, Clostridium, Erysipelothrix, Nocardia • Protozoa: Cryptosporidium

  4. Use of Xenopus spp. in Research • Frequently used as models in comparative medicine • Xenopus is used in studies of development and differentiation at both cellular and molecular levels. • Frequently used in biomedical research to study vision, hearing, respiratory physiology, endocrinology, analgesia, toxicology, tissue freezing, and tissue regeneration. • Numerous peptides of frog origin have received considerable attention as potential therapeutics for bacterial infections, allergies, asthma, central nervous disorders, and analgesics

  5. Xenopus Zoonoses • While extremely rare, there is potential for transfer of infectious agents from amphibians to man. Prominent organisms include bacterial agents such as Pseudomonas, Salmonella, and Mycobacterium, and parasites including tapeworms

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