1 / 7

Ca 2+

Acute Sulfonylurea therapy at disease onset can cause permanent remission of K ATP -induced diabetes Remedi MS et al. Diabetes . 2011; 60:2515-2522. Healthy. Neonatal Diabetes. High Glucose. Ca 2+. Mutations: KCNJ11 - ABCC8 (SUR1). Kir6.2. SUR1. Depolarization. Insulin Secretion.

anoush
Download Presentation

Ca 2+

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Acute Sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetesRemedi MS et al. Diabetes. 2011; 60:2515-2522

  2. Healthy Neonatal Diabetes High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Insulin Secretion ATP K+ High ATP/ADP ratio

  3. Healthy Neonatal Diabetes Sulfonylureas High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Different outcomes Insulin Secretion ATP K+ High ATP/ADP ratio

  4. Healthy Neonatal Diabetes Sulfonylureas High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Different outcomes Insulin Secretion ATP K+ High ATP/ADP ratio Mouse neonate • KATP dependent neonatal diabetes • Hyperglycemia • Loss of β-cells

  5. Healthy Neonatal Diabetes Sulfonylureas High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Different outcomes Insulin Secretion ATP K+ High ATP/ADP ratio Mouse neonate Sulfonylureas 6 days • KATP dependent neonatal diabetes • Hyperglycemia • Loss of β-cells Early onset of neonatal diabetes

  6. Healthy Neonatal Diabetes Sulfonylureas High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Different outcomes Sulfonylureas Insulin Secretion Not cured (70%) ATP K+ High ATP/ADP ratio Cured (30%) Fed Glucose Mouse neonate Sulfonylureas time 6 days • KATP dependent neonatal diabetes • Hyperglycemia • Loss of β-cells Early onset of neonatal diabetes Insulin Content Not Cured Cured

  7. Healthy Neonatal Diabetes Sulfonylureas High Glucose Ca2+ • Mutations: • KCNJ11 • - ABCC8 (SUR1) Kir6.2 SUR1 Depolarization Different outcomes Sulfonylureas Insulin Secretion Not cured (70%) ATP K+ High ATP/ADP ratio Cured (30%) Fed Glucose Mouse neonate Sulfonylureas time 6 days • KATP dependent neonatal diabetes • Hyperglycemia • Loss of β-cells Early onset of neonatal diabetes Insulin Content Not Cured Cured

More Related