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This article explores the process of transcription and gene regulation, including the molecular model of DNA and RNA, and the various levels of control in gene expression, such as chromatin modifications, transcription initiation, mRNA stability, translation, post-translational processing, and protein stability.
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Transcription and Gene Regulation Joyce Lloyd jlloyd@vcu.edu
Fig. 8.9 Molecular Model of DNA Cummings, Human Heredity
RNA Is Single Stranded Transfers genetic information from the nucleus to the cytoplasm Participates in protein synthesis It is a component of ribosomes Contains ribose sugar and A, U, G, and C Fig. 8.11 Cummings, Human Heredity
Transcription Fig. 9.5 Cummings, Human Heredity
Fig. 9.9a-d Cummings, Human Heredity
Fig. 9.11e-j Cummings, Human Heredity
Levels of control of gene expression • Chromatin modifications (Epigenetics) • Initiation of transcription • Alternative transcription (multiple promoters and splicing) • mRNA stability • Translation • Post-translational processing • Protein stability