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VISUALIZATION IN BIOLOGY

VISUALIZATION IN BIOLOGY. Rama Viswanathan Professor of Chemistry and Computer Science (At Beloit College since 1983). CHEMISTRY: Structure Function BIOLOGY: Structure  FunctionSequenceCell. CACHE (FUJITSU). COMPUTATIONAL CHEMISTRY PACKAGE Molecule Structure Editor

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VISUALIZATION IN BIOLOGY

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  1. VISUALIZATION IN BIOLOGY Rama Viswanathan Professor of Chemistry and Computer Science (At Beloit College since 1983)

  2. CHEMISTRY: StructureFunction • BIOLOGY: Structure FunctionSequenceCell

  3. CACHE (FUJITSU) COMPUTATIONAL CHEMISTRY PACKAGE • Molecule Structure Editor • 3-D Visualization • “Computation” of best/equilibrium structures • Applications in Biology

  4. Mycobacterium tubercolosis nucleoside phosphorylase (TB-PNP) COMPLEXED with transition state analague Immucillin-H (ImmH) and phosphate • Q) Why study? • A) Rational drug designSelective Inhibitor

  5. Import and view structure from PDB • “Clean up” • Analyze protein-ligand interactions • Import,modify, screen potential ligands • “Dock” ligands into the protein active site • Structure-Activity analysis

  6. GRAPHICAL VISUALIZATIONINSYSTEMS BIOLOGY • Metabolic and Regulatory Pathways • CONNECTIVITY • EXCEL FRONT END to sophisticated software for graphical layout: TOM SAWYER

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