PostDoc_Ad_w

1. 3 Postdoctoral, 1 predoctoral and 1 technician positions in "Mechanisms of Cancer and Metastasis" in Alicante (Spain) The project involving three interdisciplinary research groups at the Instituto de Neurociencias de Alicante (Spain) will focus on the generation and exploitation of in vivo models of tumour growth, invasion, and metastasis using C. elegans, Drosophila, mice, and cell culture. The project will combine high throughput genetic screens, direct and reverse genetics, genomics, mouse transgenesis, and biochemical analysis. Applicants for the Postdoc Positions should hold a PhD degree in a life sciences subject and should have expertise involving the following profiles: Requirements Position 1: A solid background in Genetics and Cell Biology. Previous experience with large-scale RNAi screens in C.elegans will be highly valued. Position 2: Molecular biology of cancer, neurosciencies and mouse transgenesis. Position 3: Biochemistry, cell culture and co-immunoprecipiation techniques, in addition previous experience in two-photon and confocal microscopy will be positively considered. Predoctoral, and technician positions have no specific skill requirements but experience in genetics and/or cell culture will be positively considered. Recent publications Ferres-Marco et al. (2006) Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature 439, 430-436. Palomero et al. (2007) Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med 13, 1203-1210. Islam et al. (2004) Activation of EGF Receptor Kinase by L1-mediated Homophilic Cell Interactions Mol Biol Cell 15, 2003-2012. Kristiansen et al. (2005) Genetic Analysis of an Overlapping Functional Requirement for L1- and NCAM-type Proteins During Sensory Axon Guidance in Drosophila. Mol Cell Neurosci28, 141-152. Pertusa et al. (2007) Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1.J Biol Chem 282, 28768-78. For further information and informal inquiries, please contact: Prof. M. Dominguez [m.dominguez@umh.es], Dr. H. Cabedo (hugo.cabedo@umh.es), or Dr. L. Garcia-Alonso (lgalonso@umh.es). Interested candidates should send their applications, including a CV, a brief statement of experience and interests and the names and addresses of two referees to: ALMUDENA ORTIZ <a.ortiz@umh.es>, Instituto de Neurociencias, CSIC-Universidad Miguel Hernandez, Sant Joan d'Alacant, Alicante 03550, Spain.